evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

1,266 questions · 1,314 findings · 160 reviews · Headline outcomes only

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 309 · 23.5%GRADE not reported 34 · 2.6%Very low 356 · 27.1%Low 393 · 29.9%Moderate 187 · 14.2%High 35 · 2.7%

Intervention not reported

In‐hospital death from any cause occurring within 4 weeks of randomization or the beginning of treatment · individuals with infant botulism
1 finding from 1 review

Intervention not reported

Duration of hospitalization (in weeks) · individuals with infant botulism
1 finding from 1 review

Intervention not reported

Duration of mechanical ventilation (in weeks) · individuals with infant botulism
1 finding from 1 review

Intervention not reported

Duration of tube or parenteral feeding (in weeks) · individuals with infant botulism
1 finding from 1 review

Intervention not reported

Risk of adverse events (until time of hospital discharge) · individuals with infant botulism

The intervention showed no clear difference in risk of adverse events (until time of hospital discharge) (moderate certainty).

1 finding from 1 review

Amifostine vs no otoprotective intervention

Ototoxicity according to NCI CTC v2 criteria with intra‐arterial platinum (combined asymptomatic and symptomatic disease) Exact test method not reported · children with cancer treated with platinum‐based therapy

Amifostine showed no clear difference in ototoxicity according to NCICTCv2 criteria with intra‐arterial… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Sodium thiosulfate vs no otoprotective intervention

Ototoxicity according to Brock criteria with intravenous platinum (combined asymptomatic and symptomatic disease) · children with cancer treated with platinum‐based therapy

Sodium thiosulfate probably leads to lower ototoxicity according to Brock criteria with intravenous platinum… compared with no otoprotective intervention (moderate certainty).

1 finding from 1 review

Sodium thiosulfate vs no otoprotective intervention

Overall survival with intravenous platinum (i.e. mortality/number of participants deceased) · children with cancer treated with platinum‐based therapy

Sodium thiosulfate showed no clear difference in overall survival with intravenous platinum (i.e. mortality/number of… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Sodium thiosulfate vs no otoprotective intervention

Event‐free survival · children with cancer treated with platinum‐based therapy

Sodium thiosulfate showed no clear difference in event‐free survival with intravenous platinum (i.e. number of… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Sodium thiosulfate vs no otoprotective intervention

Tumour response with intravenous platinum (complete and partial remission) · children with cancer treated with platinum‐based therapy

Sodium thiosulfate showed no clear difference in tumour response with intravenous platinum (complete and partial… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Amifostine vs no otoprotective intervention

Ototoxicity according to NCI CTC v2 criteria with intravenous platinum (combined asymptomatic and symptomatic disease) Objective and subjective audiometric evaluations were performed, no further information provided · children with cancer treated with platinum‐based therapy

Amifostine showed no clear difference in ototoxicity according to NCICTCv2 criteria with intravenous platinum… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Amifostine vs no otoprotective intervention

Ototoxicity according to modified Brock criteria with intravenous platinum (combined asymptomatic and symptomatic disease) Audiograms were performed, but no further information provided · children with cancer treated with platinum‐based therapy

Amifostine showed no clear difference in ototoxicity according to modified Brock criteria with intravenous… compared with no otoprotective intervention (low certainty).

1 finding from 1 review