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What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

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No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Hydrogel dressings vs povidone‐iodine

Time to complete healing · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

It is very uncertain whether hydrogel dressing changes time to wound healing (days) compared with wound cleaning with 10% povidone iodine (very low certainty).

1 finding from 1 review

Platelet‐rich plasma gel vs absorbent sterile cotton gauze

Time to complete healing · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

Platelet‐rich plasma gel may leads to higher time to wound healing (days) compared with absorbent sterile cotton gauze (low certainty).

1 finding from 1 review

Gentamicin‐impregnated collagen sponge vs no dressing

Time to complete healing · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

It is very uncertain whether gentamicin‐impregnated collagen sponge changes time to wound healing (days) compared with no dressing (very low certainty).

1 finding from 1 review

Dialkylcarbamoyl chloride (DACC)‐coated dressing vs alginate dressing

Proportion of wounds healed · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

It is very uncertain whether dialkylcarbamoyl chloride (DACC)‐coated dressing changes proportion of wounds healed at 25 days compared with alginate dressing (very low certainty).

1 finding from 1 review

Zinc oxide mesh vs placebo mesh

Proportion of wounds healed · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

It is very uncertain whether zinc oxide mesh changes proportion of wounds healed at 30 days compared with placebo mesh (very low certainty).

1 finding from 1 review

Duct‐to‐mucosa vs invagination pancreaticojejunostomy

Length of hospital stay · adults undergoing open pancreaticoduodenectomy

It is very uncertain whether duct‐to‐mucosa changes length of hospital stay (days) compared with invagination pancreaticojejunostomy (very low certainty).

1 finding from 1 review

Any intervention vs steroid alone or plus levofloxacin

Proportion of eyes in which SEI had developed within 21 days of treatment (lower is favored) · epidemic keratoconjunctivitis

It is very uncertain whether any intervention changes proportion of eyes in which SEI had developed within 21 days of… compared with steroid alone or plus levofloxacin (very low certainty).

1 finding from 1 review

Any intervention vs steroid alone or plus levofloxacin

Proportion of participants who discontinued medication and did not develop rebound SEI within 21 days (higher is favored) · epidemic keratoconjunctivitis

It is very uncertain whether any intervention changes proportion of participants who discontinued medication and did not… compared with steroid alone or plus levofloxacin (very low certainty).

1 finding from 1 review