Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,822 questions · 1,891 findings · 321 reviews · Headline outcomes only

No studies found 279 · 14.8%GRADE not reported 46 · 2.4%Very low 524 · 27.7%Low 571 · 30.2%Moderate 330 · 17.5%High 141 · 7.5%

Perioperative chemotherapy vs primary surgery

Overall survival by tumor site ‐ Esophagus · resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus

Perioperative chemotherapy showed no clear difference in overall survival by tumor site ‐ Esophagus compared with primary surgery (high certainty).

1 finding from 1 review

Perioperative chemotherapy vs primary surgery

Overall survival by tumor site ‐ GE junction · resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus

Perioperative chemotherapy leads to lower overall survival by tumor site ‐ GE junction compared with primary surgery (high certainty).

1 finding from 1 review

Perioperative chemotherapy vs primary surgery

Overall survival by tumor site ‐ Stomach · resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus

Perioperative chemotherapy showed no clear difference in overall survival by tumor site ‐ Stomach compared with primary surgery (high certainty).

1 finding from 1 review

Perioperative chemotherapy vs primary surgery

Overall survival by chemo‐/radiotherapy ‐ Chemotherapy only · resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus

Perioperative chemotherapy leads to lower overall survival by chemo‐/radiotherapy ‐ Chemotherapy only compared with primary surgery (high certainty).

1 finding from 1 review

Perioperative chemotherapy vs primary surgery

Overall survival by chemo‐/radiotherapy ‐ Chemoradiotherapy · resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus

Perioperative chemotherapy probably leads to lower overall survival by chemo‐/radiotherapy ‐ Chemoradiotherapy compared with primary surgery (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality · adults and children with clinical signs and symptoms of acute lower respiratory tract infection

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Time to resolution of clinical signs and symptoms [days] · adults and children with clinical signs and symptoms of acute lower respiratory tract infection
1 finding from 1 review

Intervention not reported

Hospitalisation rates · adults and children with clinical signs and symptoms of acute lower respiratory tract infection

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Complications of infection · adults and children with clinical signs and symptoms of acute lower respiratory tract infection

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse effects from chest radiographs · adults and children with clinical signs and symptoms of acute lower respiratory tract infection

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Re‐infection · children with lower urinary tract infection

It is very uncertain whether the intervention changes re‐infection (very low certainty).

1 finding from 1 review