Cochrane · systematic review · CD006857
Antibiotics for treating lower urinary tract infection in children
Fitzgerald, A, Mori, R, Lakhanpaul, M, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
17
current version
GRADE rated
17
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 17 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Single‐dose versus short‐course (3‐7 days) antibiotics for treating lower urinary tract infection in children
Population: children with lower urinary tract infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Persistent bacteriuria Single‐dose vs short‐course (3‐7 days) antibiotics | RR 1.3 [0.65, 2.62] | 2 studies · 145 participants | Very low Downgraded: risk of bias, imprecision |
Recurrence Single‐dose vs short‐course (3‐7 days) antibiotics | RR 1.5 [0.43, 5.26] | 2 studies · 145 participants | Very low Downgraded: risk of bias, imprecision |
Re‐infection Single‐dose vs short‐course (3‐7 days) antibiotics | RR 0.16 [0.02, 1.26] | 1 study · 45 participants | Very low Downgraded: risk of bias, imprecision |
Single‐dose versus conventional 10‐day antibiotic treatment for treating lower urinary tract infection in children
Population: children with lower urinary tract infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Persistent bacteriuria Single‐dose vs conventional 10‐day antibiotic treatment | RR 2.01 [1.06, 3.8] | 6 studies · 228 participants | Very low Downgraded: risk of bias |
Persistent symptoms Single‐dose vs conventional 10‐day antibiotic treatment | RR 0.29 [0.03, 2.5] | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision |
Persistent bacteriuria and symptoms Single‐dose vs conventional 10‐day antibiotic treatment | RR 1.83 [0.18, 18.84] | 1 study · 46 participants | Very low Downgraded: risk of bias, imprecision |
Recurrence Single‐dose vs conventional 10‐day antibiotic treatment | RR 1.38 [0.55, 3.5] | 2 studies · 79 participants | Very low Downgraded: risk of bias |
Short (3‐7 days) long‐course (10‐14 days) antibiotics for treating lower urinary tract infection in children
Population: children with lower urinary tract infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Persistent bacteriuria | RR 1.1 [0.68, 1.77] | 3 studies · 265 participants | Very low Downgraded: risk of bias, imprecision |
Recurrence | RR 1.14 [0.7, 1.86] | 4 studies · 363 participants | Very low |
Re‐infection | RR 0.88 [0.44, 1.74] | 2 studies · 211 participants | Very low Downgraded: risk of bias |
10‐day trimethoprim versus 10‐day trimethoprim+sulfamethoxazole for treating lower urinary tract infection in children
Population: children with lower urinary tract infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Persistent bacteriuria 10‐day trimethoprim vs 10‐day trimethoprim+sulfamethoxazole | RR 1.93 [0.38, 9.76] | 1 study · 59 participants | Very low Downgraded: risk of bias, imprecision |
Persistent symptoms 10‐day trimethoprim vs 10‐day trimethoprim+sulfamethoxazole | RR 4.84 [0.24, 96.66] | 1 study · 59 participants | Very low Downgraded: risk of bias, imprecision |
Recurrence 10‐day trimethoprim vs 10‐day trimethoprim+sulfamethoxazole | RR 2.9 [0.12, 68.5] | 1 study · 59 participants | Very low Downgraded: risk of bias, imprecision |
10‐day cefadroxil versus 10‐day ampicillin for treating lower urinary tract infection in children
Population: children with lower urinary tract infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Persistent bacteriuria 10‐day cefadroxil vs 10‐day ampicillin | RR 0.33 [0.01, 7.62] | 1 study · 32 participants | Very low Downgraded: risk of bias, imprecision |
Persistent symptoms 10‐day cefadroxil vs 10‐day ampicillin | RR 0.33 [0.01, 7.62] | 1 study · 32 participants | Very low Downgraded: risk of bias, imprecision |
Single‐dose fosfomycin versus single‐dose netilmicin for treating lower urinary tract infection in children
Population: children with lower urinary tract infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Persistent bacteriuria Single‐dose fosfomycin vs single‐dose netilmicin | RR 3.15 [0.68, 14.64] | 1 study · 135 participants | Very low Downgraded: risk of bias |
Recurrence Single‐dose fosfomycin vs single‐dose netilmicin | RR 0.63 [0.26, 1.56] | 1 study · 135 participants | Very low Downgraded: risk of bias |