Overall survival, induction cisplatin + 5-fluorouracil prior to concurrent chemoradiation (cisplatin) vs concurrent chemoradiation (cisplatin) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Induction chemotherapy plus locoregional treatment (radiotherapy… showed no clear difference in overall survival, induction cisplatin + 5-fluorouracil prior to… compared with locoregional treatment (radiotherapy and/or surgery) alone (low certainty).
1 finding from 1 review
Amount of crowding · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
It is very uncertain whether lacebacks with fixed appliances changes amount of crowding (change) at 6 months compared with fixed appliances only (control) (very low certainty).
1 finding from 1 review
Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
Removable tooth-borne expansion (expansion plate) probably leads to higher molar expansion (inter-molar distance) compared with observation (no treatment) (moderate certainty).
1 finding from 1 review
Costs and cost‐effectiveness · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
The review found no eligible studies for this question.
1 finding from 1 review
Harms (discomfort) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
1 finding from 1 review
Specificity · Adults (aged 16 years or over) presenting to primary or secondary care with clinically evident suspicious or innocuous oral lesions
1 finding from 1 review
Specificity for detection of oral cavity cancer/OPMD · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…
1 finding from 1 review
Summary of findings 2 (no pooled analysis): specificity 1.00 (95% CI 1.00 to 1.00), 0.95 (95% CI 0.88 to 0.99), 0.44 (95% CI 0.20 to 0.70), and 0.54 (95% CI 0.37 to 0.69) across the 4 studies. Certainty VERY LOW.
4 studies · 35059 participants
Very low
Heart rate · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
Periodontal treatment (subgingival SRP with or without other… showed no clear difference in heart rate compared with no treatment (no periodontal treatment); GRADE not reported.
1 finding from 1 review
Lesion progression · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
1 finding from 1 review
Need for additional augmentation prior to implant placement · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
It is very uncertain whether ARP with xenograft (bone graft) changes need for additional augmentation prior to implant placement compared with extraction alone (very low certainty).
1 finding from 1 review
Need for additional augmentation prior to implant placement · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
It is very uncertain whether ARP with allograft changes need for additional augmentation prior to implant placement compared with ARP with xenograft (very low certainty).
1 finding from 1 review
Specificity for detection of oral cavity cancer/OPMD · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…
1 finding from 1 review
Summary of findings 1 (no pooled analysis): for the 7 low-prevalence studies specificity ranged from 0.94 (95% CI 0.88 to 0.97) to 0.99 (95% CI 0.98 to 1.00); for the 3 higher-prevalence studies specificity ranged from…
10 studies · 25568 participants
Low
Size of the lower jaw (arch length, change) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
Extraction of third molars (wisdom teeth) led to higher size of the lower jaw (arch length, change) compared with no active treatment (control); GRADE not reported.
1 finding from 1 review
Complications (e.g. discomfort, pain and swelling) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
1 finding from 1 review
1 trial (Patel 2013) reported pain, swelling, membrane exposure and partial loss of grafting material, while the other trial (Gholami 2012) reported that the procedure was uneventful
2 studies · 37 participants
Low
Implant failure rate · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
The review found no eligible studies for this question.
1 finding from 1 review
Outcome not reported
0 studies
No studies found
Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review
Signs and symptoms of temporomandibular joint dysfunction · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Harms: injury · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6 to 12 years)
The review found no eligible studies for this question.
1 finding from 1 review
Success rate (radiographically‐assessed healing of cyst healing based on the Neer/Cole rating system) · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…
Mineral trioxide aggregate (MTA) showed no clear difference in success rate at 2 years compared with intermediate restorative material (IRM); GRADE not reported.
1 finding from 1 review
RR 1.05 [0.92, 1.20]
1 study
GRADE not reported
Lower incisors to mandible (position, mm) at 9 months · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
Lower lingual arch led to higher lower incisors to mandible at 1 year compared with no active treatment (control); GRADE not reported.
1 finding from 1 review