Intervention not reported
Relapse Proportion of participants with relapse at a maximum of five years'
The intervention may leads to lower relapse Proportion of participants with relapse at a maximum of five… (low certainty).
1 finding from 1 review
OR 0.35 [0.26, 0.48]
Studies not reported
Low
Primary anaesthesia failure (incomplete sensory block) · Adult patients undergoing hand, wrist or forearm surgery
Double leads to lower primary anaesthesia failure (incomplete sensory block) compared with single‐injection technique (high certainty).
1 finding from 1 review
Secondary analgesia failure: Intraoperative sedation required · Adult patients undergoing hand, wrist or forearm surgery
Double showed no clear difference in secondary analgesia failure ‐ intraoperative sedation required compared with single‐injection technique (moderate certainty).
1 finding from 1 review
Secondary analgesia failure : Tourniquet pain · Adult patients undergoing hand, wrist or forearm surgery
Double showed no clear difference in secondary analgesia failure ‐ tourniquet pain compared with single‐injection technique (moderate certainty).
1 finding from 1 review
Complete failure of block3 · Adult patients undergoing hand, wrist or forearm surgery
Double showed no clear difference in complete failure of block3 compared with single‐injection technique (low certainty).
1 finding from 1 review
Time to readiness for surgery2 (minutes) · Adult patients undergoing hand, wrist or forearm surgery
1 finding from 1 review
Intravascular injection · Adult patients undergoing hand, wrist or forearm surgery
Double showed no clear difference in intravascular injection compared with single‐injection technique (low certainty).
1 finding from 1 review
Adverse effects lasting more than 24 hours3 · Adult patients undergoing hand, wrist or forearm surgery
1 finding from 1 review
Intervention not reported
Clearance of proven sepsis · neonates with suspected or proven sepsis
It is very uncertain whether the intervention changes clearance of proven sepsis (very low certainty).
1 finding from 1 review
Intervention not reported
Failure to achieve peak levels of at least 5 microgram/ml (measured 0.5 to one hour after administration of any dose of gentamicin) · neonates with suspected or proven sepsis
The intervention probably leads to lower failure to achieve peak levels of at least 5 microgram/ml (measured… (moderate certainty).
1 finding from 1 review
Intervention not reported
Nephrotoxicity (End of study period or before discharge) · neonates with suspected or proven sepsis
1 finding from 1 review
Intervention not reported
Ototoxicity (End of study period or before discharge) · neonates with suspected or proven sepsis
It is very uncertain whether the intervention changes ototoxicity (End of study period or before discharge) (very low certainty).
1 finding from 1 review
Intervention not reported
Failure to achieve trough levels of ≤2 microgram/ml ( · neonates with suspected or proven sepsis
The intervention probably leads to lower failure to achieve trough levels of ≤2 microgram/ml ( (moderate certainty).
1 finding from 1 review
Hypertensive disorders of pregnancy · pregnant women with diabetes
1 finding from 1 review
Adiposity (infant) · infants of pregnant women with diabetes
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Neurosensory disability · infants of pregnant women with diabetes
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Caesarean section · pregnant women with diabetes
It is very uncertain whether CSII changes caesarean section compared with MDI: maternal outcomes (very low certainty).
1 finding from 1 review
Development of type 2 diabetes · pregnant women with diabetes
1 finding from 1 review
Perineal trauma · pregnant women with diabetes
1 finding from 1 review
Return to pre‐pregnancy weight · pregnant women with diabetes
1 finding from 1 review