Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Pyronaridine‐artesunate (PY‐AS) vs mefloquine plus artesunate (MQ + AS)

First treatment, abnormal AST increase (42 days) · adults and children with uncomplicated P falciparum malaria

It is very uncertain whether pyronaridine‐artesunate (PY‐AS) changes first treatment, abnormal AST increase (42 days) compared with mefloquine plus artesunate (MQ + AS) (very low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs mefloquine plus artesunate (MQ + AS)

First treatment, abnormal bilirubin increase (42 days) · adults and children with uncomplicated P falciparum malaria

It is very uncertain whether pyronaridine‐artesunate (PY‐AS) changes first treatment, abnormal bilirubin increase (42 days) compared with mefloquine plus artesunate (MQ + AS) (very low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs artemether‐lumefantrine (AL)

Total failure: day 28 (unadjusted) · adults and children with uncomplicated P falciparum malaria

Pyronaridine‐artesunate (PY‐AS) may leads to lower total failure: day 28 (unadjusted) compared with artemether‐lumefantrine (AL) (low certainty).

2 findings from 1 review

Pyronaridine‐artesunate (PY‐AS) vs artemether‐lumefantrine (AL)

Serious adverse events (42 days) · adults and children with uncomplicated P falciparum malaria

Pyronaridine‐artesunate (PY‐AS) showed no clear difference in serious adverse events (42 days) compared with artemether‐lumefantrine (AL) (low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs artemether‐lumefantrine (AL)

First treatment, abnormal ALT increase (42 days) · adults and children with uncomplicated P falciparum malaria

Pyronaridine‐artesunate (PY‐AS) may leads to higher first treatment, abnormal ALT increase (42 days) compared with artemether‐lumefantrine (AL) (low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs artemether‐lumefantrine (AL)

First treatment, abnormal AST increase (42 days) · adults and children with uncomplicated P falciparum malaria

Pyronaridine‐artesunate (PY‐AS) may leads to higher first treatment, abnormal AST increase (42 days) compared with artemether‐lumefantrine (AL) (low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs artemether‐lumefantrine (AL)

First treatment, abnormal bilirubin increase (42 days) · adults and children with uncomplicated P falciparum malaria

Pyronaridine‐artesunate (PY‐AS) showed no clear difference in first treatment, abnormal bilirubin increase (42 days) compared with artemether‐lumefantrine (AL) (low certainty).

1 finding from 1 review

Oral vs vaginal administration of oestradiol and dydrogesterone

Uterine volume (cm³) · women with premature ovarian insufficiency (POI) awaiting oocyte donation
2 findings from 1 review

Oral vs vaginal administration of oestradiol and dydrogesterone

Endometrial thickness (mm) · women with premature ovarian insufficiency (POI) awaiting oocyte donation
2 findings from 1 review

Enhanced recovery protocol vs traditional care

Overall postoperative complications (within 30 days of operation) · women with gynaecological cancers

Enhanced recovery after surgery programme showed no clear difference in overall postoperative complications (within 30 days of operation) compared with traditional care (low certainty).

1 finding from 1 review

Intervention not reported

Primary ‐ Short‐term complications (abscess, perforation, obstruction or fistula) within 30 days · Patients with acute uncomplicated diverticulitis

The intervention showed no clear difference in primary ‐ Short‐term complications (abscess, perforation,… (low certainty).

1 finding from 1 review

Intervention not reported

Primary ‐ Short‐term complications (abscess, perforation, obstruction or fistula) within 30 days · Patients with acute uncomplicated diverticulitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Primary ‐ Short‐term emergency surgery within 30 days · Patients with acute uncomplicated diverticulitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Primary ‐ Short‐term emergency surgery within 30 days · Patients with acute uncomplicated diverticulitis

The intervention showed no clear difference in primary ‐ Short‐term emergency surgery within 30 days (low certainty).

1 finding from 1 review

Intervention not reported

Primary ‐ Short‐term complications (abscess, perforation, obstruction or fistula) within 30 days · Patients with acute uncomplicated diverticulitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Primary ‐ Short‐term emergency surgery within 30 days · Patients with acute uncomplicated diverticulitis

The intervention showed no clear difference in primary ‐ Short‐term emergency surgery within 30 days (low certainty).

1 finding from 1 review