Findings

What do systematic reviews say?

1,550 questions · 1,617 findings · 161 reviews · Neonatal

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No studies found 238 · 14.7%GRADE not reported 76 · 4.7%Very low 377 · 23.3%Low 567 · 35.1%Moderate 285 · 17.6%High 74 · 4.6%

Left lateral horizontal vs left lateral elevated positioning

Episodes of apnoea · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 87 participants
Very low

Supine vs prone positioning

Episodes of bradycardia · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 72 participants
Very low

Left lateral horizontal vs left lateral elevated positioning

Episodes of oxygen desaturation · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 87 participants
Very low

Left lateral horizontal vs left lateral elevated positioning

Episodes of severe apnoea · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 87 participants
Very low

Left lateral horizontal vs left lateral elevated positioning

Episodes of bradycardia · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 87 participants
Very low

Left lateral horizontal vs left lateral elevated positioning

Episodes of severe bradycardia · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 87 participants
Very low

Prone horizontal vs right lateral horizontal positioning

Episodes of apnoea · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 130 participants
Very low

Prone horizontal vs right lateral horizontal positioning

Episodes of oxygen desaturation · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 88 participants
Very low

Prone horizontal vs right lateral horizontal positioning

Episodes of severe apnoea · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 88 participants
Very low

Prone horizontal vs right lateral horizontal positioning

Episodes of bradycardia · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 88 participants
Very low

Prone horizontal vs right lateral horizontal positioning

Episodes of severe bradycardia · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 88 participants
Very low

Prone horizontal vs left lateral horizontal positioning

Episodes of apnoea · spontaneously breathing preterm infants with apnoea

1 finding from 1 review

Body positioning for spontaneously breathing preterm infants with apnoea 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 131 participants
Low

Fluid restricted vs liberal fluids compared to placebo

Duration of oxygen therapy (hours) · preterm infants with chronic lung disease

1 finding from 1 review

Fluid restriction for treatment of preterm infants with chronic lung disease 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Fluid restricted vs liberal fluids compared to placebo

Length of hospital stay · preterm infants with chronic lung disease

1 finding from 1 review

Fluid restriction for treatment of preterm infants with chronic lung disease 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Fluid restricted vs liberal fluids compared to placebo

Daily weight gain · preterm infants with chronic lung disease

1 finding from 1 review

Fluid restriction for treatment of preterm infants with chronic lung disease 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Fluid restricted vs liberal fluids compared to placebo

Proportion with apnoea · preterm infants with chronic lung disease

Fluid restricted showed no clear difference in proportion with apnoea compared with liberal fluids compared to placebo (low certainty).

1 finding from 1 review

Fluid restriction for treatment of preterm infants with chronic lung disease 2017 · Cochrane Headline outcomes only
RR 1.35 [0.98, 1.86]
1 study · 60 participants
Low

Intervention not reported

Death or major disability by 18 to 24 months corrected age (aligned definition) · extremely preterm infants

The intervention showed no clear difference in death or major disability by 18 to 24 months corrected age (aligned… (high certainty).

1 finding from 1 review

Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants 2017 · Cochrane Headline outcomes only
RR 1.04 [0.98, 1.1]
5 studies · 4754 participants
High

Intervention not reported

Death to 18 to 24 months corrected age · extremely preterm infants

The intervention leads to higher death to 18 to 24 months corrected age (high certainty).

1 finding from 1 review

Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants 2017 · Cochrane Headline outcomes only
RR 1.16 [1.03, 1.31]
5 studies · 4873 participants
High

Intervention not reported

Major disability by 18 to 24 months corrected age (aligned definition) · extremely preterm infants

The intervention showed no clear difference in major disability by 18 to 24 months corrected age (aligned definition) (high certainty).

1 finding from 1 review

Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants 2017 · Cochrane Headline outcomes only
RR 1.01 [0.93, 1.09]
5 studies · 3867 participants
High

Intervention not reported

Necrotising enterocolitis · extremely preterm infants

The intervention leads to higher necrotising enterocolitis (high certainty).

1 finding from 1 review

Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants 2017 · Cochrane Headline outcomes only
RR 1.24 [1.05, 1.47]
5 studies · 4929 participants
High