Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,718 questions · 1,762 findings · 100 reviews · Headline outcomes only

No studies found 507 · 28.8%GRADE not reported 115 · 6.5%Very low 556 · 31.6%Low 444 · 25.2%Moderate 114 · 6.5%High 26 · 1.5%

Intervention not reported

Any upper gastrointestinal bleeding in infants at risk of upper gastrointestinal bleeding · newborn infants at risk of gastrointestinal bleeding

The intervention probably leads to lower any upper gastrointestinal bleeding in infants at risk of upper… (moderate certainty).

1 finding from 1 review

NSAIDs vs control or placebo medications

Adverse event nausea and vomiting (0 to 24 hours) · adults undergoing brain surgery

Nonsteroidal anti‐inflammatory drugs (NSAIDs) showed no clear difference in adverse event nausea and vomiting (0 to 24 hours) compared with control or placebo medications (low certainty).

1 finding from 1 review

Dexmedetomidine vs control or placebo medications

Adverse event nausea and vomiting (0 to 24 hours) · adults undergoing brain surgery

Dexmedetomidine showed no clear difference in adverse event nausea and vomiting (0 to 24 hours) compared with control or placebo medications (low certainty).

1 finding from 1 review