Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,340 questions · 1,512 findings · 205 reviews

No studies found 317 · 21%GRADE not reported 358 · 23.7%Very low 356 · 23.5%Low 271 · 17.9%Moderate 173 · 11.4%High 37 · 2.4%

Chloral hydrate oral (50 mg/kg) vs sodium thiopental rectal (25 mg/kg)

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in proportion of children who had sedation failure or inadequate level… compared with sodium thiopental rectal (25 mg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs sodium thiopental rectal (25 mg/kg)

Number of children with clinical adverse event: oxygen desaturation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse event: desaturation compared with sodium thiopental rectal (25 mg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs sodium thiopental rectal (25 mg/kg)

Number of children with clinical adverse event: diarrhoea · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) probably leads to lower number of children with clinical adverse event: diarrhoea compared with sodium thiopental rectal (25 mg/kg) (moderate certainty).

1 finding from 1 review

Traditional suburethral sling operation vs open abdominal retropubic suspension

Number of continent (dry) women (any definition) in the medium term (1 to 5 years) · women with urinary incontinence

Traditional suburethral sling operation probably leads to higher number of continent (dry) women (any definition) in the medium term… compared with open abdominal retropubic colposuspension (moderate certainty).

1 finding from 1 review

Traditional suburethral sling operation vs open abdominal retropubic suspension

Repeat surgery for urinary incontinence‐stress urinary incontinence (symptoms only) · women with urinary incontinence

Traditional suburethral sling operation leads to lower repeat surgery for urinary incontinence‐stress urinary incontinence… compared with open abdominal retropubic colposuspension (high certainty).

1 finding from 1 review

Traditional suburethral sling operation vs open abdominal retropubic suspension

Perioperative surgical complications · women with urinary incontinence

It is very uncertain whether traditional suburethral sling operation changes perioperative surgical complications compared with open abdominal retropubic colposuspension (very low certainty).

1 finding from 1 review

Traditional suburethral sling operation vs open abdominal retropubic suspension

Long‐term adverse effects Number of women with recurrent UTIs at > 5 years · women with urinary incontinence

Traditional suburethral sling operation showed no clear difference in long‐term adverse effects Number of women with recurrent UTIs at > 5… compared with open abdominal retropubic colposuspension (low certainty).

1 finding from 1 review

color contrast: black vs dark brown/light brown/yellow vs hardness contrast: soft vs medium/hard

total microbial load (log10 CFU) · humans with open primary dentine caries

In one study, hardness category differences exceeded color category differences; no meta-analysis was conducted.

1 finding from 1 review

Mineral trioxide aggregate (MTA) pulpotomy dressing vs Platelet-rich fibrin (PRF)

Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years

A single RCT found no difference in pulpotomy success between MTA and platelet-rich fibrin (both 100% through 24 months; not pooled; ungraded).

1 finding from 1 review

Mineral trioxide aggregate (MTA) pulpotomy dressing vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years

MTA and calcium hydroxide had similar clinical and radiographic pulpotomy success at 6 months (RR 1.00, 95% CI 0.94 to 1.06; 2 RCTs; ungraded).

2 findings from 1 review