Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,085 questions · 1,232 findings · 66 reviews · Oral Health

No studies found 218 · 17.7%GRADE not reported 745 · 60.5%Very low 179 · 14.5%Low 65 · 5.3%Moderate 25 · 2%High 0 · 0%

Periodontal treatment: scaling and root planing (SRP) plus advice vs Community care: advice only

All CVD-related death · Patients with cardiovascular disease and chronic periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Periodontal treatment: scaling and root planing (SRP) plus advice vs Community care: advice only

Cardiovascular events · Patients with cardiovascular disease and chronic periodontitis
1 finding from 1 review

HVGIC Fuji IX Gold Label vs HVGIC Vitro Molar and Maxxion R

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; failure rates were tabulated.

1 finding from 1 review

CD4+ T-cell count below 250 cells/mm3 vs CD4+ T-cell count >=250 cells/mm3

HIV-related oral lesions · Children and adolescents living with HIV on ART/HAART

Lower CD4+ counts (<250 cells/mm3) were associated with roughly twice the odds of HIV-related oral lesions in two studies (not pooled).

1 finding from 1 review
  • Oral Health Status of Children and Adolescents Living with HIV Undergoing Antiretroviral Therapy: A Systematic Review… 2022 All outcomes
    Cross-sectional (case-control; single time point) · HIV pediatric/ART clinics, AIDS centers, and hospitals in Brazil, India, Saudi Arabia, and West Africa (Cote d'Ivoire, Mali, Senegal) · CD4+ T-cell count <250 cells/mm3 vs higher
    CLWH with CD4+ <250 cells/mm3 were about twice as likely to have HIV-related oral lesions: Baghirath 2013 OR 1.916 (95% CI 0.613 to 2.513), p=0.001; Divakar 2015 OR 1.999 (95% CI 0.129 to 3.688), p=0.001. Not pooled.
    2 studies
    GRADE not reported

Conventional GIC vs Compomer and glass carbomer

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; cumulative failure was highest for glass carbomer.

1 finding from 1 review

Amoxicillin + metronidazole + SRP vs Supragingival scaling (plus placebo)

All CVD-related death · People with periodontitis and metabolic syndrome (no CVD; primary prevention)

It is very uncertain whether scaling and root planing (SRP) plus antibiotics (amoxicillin and… changes all CVD-related death compared with supragingival scaling (plus placebo) (very low certainty).

1 finding from 1 review

High-viscosity glass-ionomer cement (HVGIC) restoration (conventional restorative approach) vs Resin composite restoration

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; composite resin outperformed HVGIC in the review narrative.

1 finding from 1 review

HVGIC with chlorhexidine cavity disinfectant vs HVGIC without cavity disinfectant

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; cavity disinfectant did not affect success in the review narrative.

1 finding from 1 review

Amalgam vs Light-cured compomer (polyacid-modified composite resin)

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; the review described similar clinical performance.

1 finding from 1 review

Compomer (Dyract) vs HVGIC Equia Forte and Chemfil Rock

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; compomer had more favorable retention in the review narrative.

1 finding from 1 review

ART/HAART duration <3 years vs ART/HAART duration >=3 years

Oral candidiasis · Children and adolescents living with HIV on ART/HAART

Oral candidiasis prevalence differed by ART duration (OR 17.93, 95% CI 3.69 to 83.12).

1 finding from 1 review

Resin-modified glass ionomer cement for bonding orthodontic brackets vs Compomer and composite resin

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; failure rates were tabulated by arm.

1 finding from 1 review