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What do systematic reviews say?

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Evidence found and GRADE certainty

3,696 questions · 3,815 findings · 855 reviews

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No studies found 573 · 15%GRADE not reported 374 · 9.8%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Remdesivir and standard care vs placebo or usual care

In‐hospital mortality at up to day 150 · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care showed no clear difference in in‐hospital mortality at up to day 150 compared with standard care (plus/minus placebo) (moderate certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Clinical improvement: discharged alive ( · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care probably leads to higher clinical improvement: participants alive and ready to be discharged… compared with standard care (plus/minus placebo) (moderate certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Clinical worsening: new need for invasive mechanical ventilation or death · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care probably leads to lower clinical worsening: time to new need for invasive mechanical… compared with standard care (plus/minus placebo) (moderate certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Adverse events: all grades · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care showed no clear difference in adverse events (any grade) at up to day 28 compared with standard care (plus/minus placebo) (low certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Serious adverse events at up to day 28 · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care showed no clear difference in serious adverse events at up to day 28 compared with standard care (plus/minus placebo) (low certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Clinical improvement: participants with symptom alleviation at up to day 14 · non‐hospitalised adults with mild COVID‐19

It is very uncertain whether remdesivir and standard care changes clinical improvement: participants with symptom alleviation at up to… compared with standard care (plus/minus placebo) (very low certainty).

1 finding from 1 review

Intervention not reported

28‐day all‐cause mortality · hospitalised adults with COVID‐19 (moderate to severe disease)

The intervention probably leads to lower 28‐day all‐cause mortality (moderate certainty).

1 finding from 1 review

Intervention not reported

Thrombotic events up to day 45 · non‐hospitalised adults with mild COVID‐19

The intervention showed no clear difference in thrombotic events up to day 45 (low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events up to day 45 · non‐hospitalised adults with mild COVID‐19

The intervention showed no clear difference in serious adverse events up to day 45 (low certainty).

1 finding from 1 review

Intervention not reported

Worsening up to day 28: participants with new need for invasive mechanical ventilation or death · hospitalised adults with COVID‐19 (moderate to severe disease)

The intervention showed no clear difference in worsening up to day 28: participants with new need for invasive… (moderate certainty).

1 finding from 1 review

Intervention not reported

Improvement up to day 28: participants discharged alive · hospitalised adults with COVID‐19 (moderate to severe disease)

The intervention showed no clear difference in improvement up to day 28: participants discharged alive (moderate certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality at day 45 · non‐hospitalised adults with mild COVID‐19

The intervention showed no clear difference in all‐cause mortality at day 45 (low certainty).

1 finding from 1 review

Intervention not reported

Admission to hospital or death up to day 45 · non‐hospitalised adults with mild COVID‐19

It is very uncertain whether the intervention changes admission to hospital or death up to day 45 (very low certainty).

1 finding from 1 review

Summary of findings table ‐ mesh repair vs non‐mesh repair

Surgical site infection · adult patients with incarcerated or strangulated groin hernia

It is very uncertain whether summary of findings table ‐ mesh repair changes surgical site infections within 30 days of repair compared with non‐mesh repair (very low certainty).

1 finding from 1 review

Summary of findings table ‐ mesh repair vs non‐mesh repair

Mortality within 30 days of repair · adult patients with incarcerated or strangulated groin hernia

It is very uncertain whether summary of findings table ‐ mesh repair changes mortality within 30 days of repair compared with non‐mesh repair (very low certainty).

1 finding from 1 review