Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,678 questions · 4,859 findings · 283 reviews

No studies found 1,225 · 25.2%GRADE not reported 215 · 4.4%Very low 1,241 · 25.5%Low 1,210 · 24.9%Moderate 776 · 16%High 192 · 4%

Summary of findings: Sodium butyrate vs placebo

Acute and late GI toxicity (grade 2+) · Men undergoing RT for prostate cancer

Summary of findings: Sodium butyrate showed no clear difference in acute and late GI toxicity (grade 2+) compared with placebo (moderate certainty).

1 finding from 1 review

Metformin vs megestrol

Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin changes regression of endometrial hyperplasia (with or without atypia) to… compared with megestrol (very low certainty).

1 finding from 1 review

Metformin vs megestrol

Hysterectomy rate · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin changes hysterectomy rate compared with megestrol (very low certainty).

1 finding from 1 review

Metformin vs megestrol

Abnormal uterine bleeding · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin changes abnormal uterine bleeding compared with megestrol (very low certainty).

1 finding from 1 review