Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,587 questions · 5,761 findings · 495 reviews

No studies found 1,011 · 17.5%GRADE not reported 1,797 · 31.2%Very low 1,100 · 19.1%Low 1,052 · 18.3%Moderate 649 · 11.3%High 152 · 2.6%

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Oral magnesium vs placebo/no treatment

Side effects (any reported throughout the intervention period) (ALL) · treating leg cramps in pregnancy

Oral magnesium showed no clear difference in side effects ‐ any compared with placebo/no treatment (low certainty).

1 finding from 1 review

Oral magnesium vs placebo/no treatment

Frequency of leg cramps after treatment: never · treating leg cramps in pregnancy

Oral magnesium may leads to higher frequency of leg cramps after treatment: never compared with placebo/no treatment (low certainty).

1 finding from 1 review

Oral magnesium vs placebo/no treatment

Frequency: 50% reduction in number of leg cramps · treating leg cramps in pregnancy

Oral magnesium may leads to higher frequency: 50% reduction in number of leg cramps compared with placebo/no treatment (low certainty).

1 finding from 1 review

Oral magnesium vs placebo/no treatment

Intensity of pain during treatment: mean total scale points The degree of pain was noted in the form, on a scale from 0 to 4 measured over 4 days and nights (0 = no pain, 1 = light pain, 2 = medium pain, 3=strong pain, 4=extreme pain) · treating leg cramps in pregnancy
1 finding from 1 review

Oral magnesium vs placebo/no treatment

At least 50% reduction in pain · treating leg cramps in pregnancy

It is very uncertain whether oral magnesium changes intensity of pain: 50% reduction in pain score 100‐mm visual… compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Oral magnesium vs placebo/no treatment

Duration of leg cramps: persisting symptoms after night‐time cramps Always · treating leg cramps in pregnancy

Oral magnesium may leads to lower duration of leg cramps: persisting symptoms after night‐time cramps… compared with placebo/no treatment (low certainty).

1 finding from 1 review

Oral magnesium vs placebo/no treatment

Duration of leg cramps: persisting symptoms after night‐time cramps Sometimes · treating leg cramps in pregnancy

It is very uncertain whether oral magnesium changes duration of leg cramps: persisting symptoms after night‐time cramps… compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Oral magnesium vs placebo/no treatment

Composite outcome: symptoms of leg cramps (intensity and frequency) Partial improvement: decrease in intensity and frequency · treating leg cramps in pregnancy

It is very uncertain whether oral magnesium changes composite outcome: symptoms of leg cramps (intensity and frequency)… compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Oral midazolam vs placebo

Level of sedation on a sedation assessment scale · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy
1 finding from 1 review

Oral midazolam vs placebo

Anxiety · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy
1 finding from 1 review

Oral midazolam vs placebo

Incomplete procedure · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy
1 finding from 1 review

Oral midazolam vs placebo

Anterograde amnesia (defined by number of participants who recalled the procedure) · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs placebo

Disinhibition or excitation · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs placebo

Discomfort/pain · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy
1 finding from 1 review