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Evidence found and GRADE certainty

766 questions · 806 findings · 76 reviews · ENT

No studies found 293 · 36.4%GRADE not reported 6 · 0.7%Very low 244 · 30.3%Low 170 · 21.1%Moderate 85 · 10.5%High 8 · 1%

Adenoidectomy and bilateral ventilation tubes vs bilateral ventilation tubes only

Specific adverse events: haemorrhage · children aged 6 months to 12 years with otitis media with effusion (OME)

Adenoidectomy and bilateral ventilation tubes showed no clear difference in adverse event: haemorrhage № of participants: 791(2 RCTs) compared with bilateral ventilation tubes only (low certainty).

1 finding from 1 review

Adenoidectomy and unilateral ventilation tube vs unilateral ventilation tube only

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and unilateral ventilation tube changes hearing: proportion of children with hearing returned to normal (12… compared with unilateral ventilation tube only (very low certainty).

1 finding from 1 review

Autoinflation vs no treatment

Proportion of children whose hearing is normal · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether autoinflation changes proportion of children whose hearing is normal compared with no treatment (very low certainty).

1 finding from 1 review

Autoinflation vs no treatment

Pain and distress related to the procedure: otalgia · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether autoinflation changes pain and distress related to the procedure: otalgia compared with no treatment (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether antibiotics changes hearing ‐ return to normal hearing (as complete improvement in… compared with placebo (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether antibiotics changes presence/persistence of OME compared with placebo (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Adverse event: anaphylaxis · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether antibiotics changes adverse event: anaphylaxis compared with placebo (very low certainty).

1 finding from 1 review

Antibiotics vs no treatment

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

Antibiotics may leads to lower presence/persistence of OME (up to 3 months) № of participants: 542… compared with no treatment (low certainty).

1 finding from 1 review

Oral steroids vs placebo

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

Oral steroids showed no clear difference in hearing ‐ return to normal hearing compared with placebo (moderate certainty).

1 finding from 1 review

Intranasal steroid spray vs placebo

Adverse event: systemic corticosteroid side effects · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether topical (intranasal) steroids changes adverse event: systemic corticosteroid side effects compared with placebo (very low certainty).

1 finding from 1 review