What do systematic reviews say?

Probiotics vs control

• Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  54 studies · 10484 participants
  Moderate

Probiotics vs control

• Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  49 studies · 9876 participants
  Moderate

Probiotics vs control

• Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1518 participants
  Low

Probiotics vs control

• Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 1836 participants
  Low

Probiotics vs control

• Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 1723 participants
  Low

Probiotics vs control

• Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 1533 participants
  Low

Probiotics vs control

The review found no eligible studies for this question.

• Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prebiotic vs control

• Prebiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 686 participants
  Low

Prebiotic vs control

• Prebiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 686 participants
  Low

Prebiotic vs control

• Prebiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 686 participants
  Low

Prebiotic vs control

• Prebiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 76 participants
  Very low

Prebiotic vs control

• Prebiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 68 participants
  Very low

Prebiotic vs control

• Prebiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 76 participants
  Very low

Paracetamol vs ibuprofen

Paracetamol showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with ibuprofen (moderate certainty).

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  RR 1.02 [0.88, 1.18]
  18 studies · 1535 participants
  Moderate

Early paracetamol vs placebo or no intervention

Early paracetamol may leads to lower failure of PDA closure after first course of treatment (by… compared with placebo/no intervention (low certainty).

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  RR 0.35
  2 studies · 127 participants
  Low

Early paracetamol vs placebo or no intervention

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Early paracetamol vs placebo or no intervention

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Late paracetamol vs placebo or no intervention

Late paracetamol showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with placebo/no intervention (low certainty).

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  RR 0.85 [0.72, 1.01]
  1 study · 55 participants
  Low

Late paracetamol vs placebo or no intervention

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Late paracetamol vs placebo or no intervention

Late paracetamol showed no clear difference in necrotizing enterocolitis during initial hospital stay (by… compared with placebo/no intervention (low certainty).

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  RR 1.04 [0.07, 15.76]
  1 study · 55 participants
  Low