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What do systematic reviews say?

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Evidence found and GRADE certainty

157 questions · 161 findings · 17 reviews · Neonatal

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No studies found 41 · 25.5%GRADE not reported 3 · 1.9%Very low 24 · 14.9%Low 37 · 23%Moderate 54 · 33.5%High 2 · 1.2%

Targeted individualized vs standard non‐individualized fortification

In‐hospital mortality · promoting growth and development in very low birth weight infants receiving human milk

It is very uncertain whether targeted individualized changes in‐hospital mortality compared with standard non‐individualized fortification (very low certainty).

1 finding from 1 review

Targeted individualized vs standard non‐individualized fortification

Necrotising enterocolitis · promoting growth and development in very low birth weight infants receiving human milk

It is very uncertain whether targeted individualized changes necrotizing enterocolitis compared with standard non‐individualized fortification (very low certainty).

1 finding from 1 review

Targeted individualized vs standard non‐individualized fortification

Culture‐proven late‐onset bacterial sepsis · promoting growth and development in very low birth weight infants receiving human milk

It is very uncertain whether targeted individualized changes culture‐proven late‐onset bacterial sepsis compared with standard non‐individualized fortification (very low certainty).

1 finding from 1 review

Adjustable individualized fortification vs standard non‐individualized fortification

Culture‐proven late‐onset sepsis · promoting growth and development in very low birth weight infants receiving human milk

The review found no eligible studies for this question.

1 finding from 1 review