Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

370 questions · 394 findings · 64 reviews

No studies found 88 · 22.3%GRADE not reported 20 · 5.1%Very low 74 · 18.8%Low 115 · 29.2%Moderate 87 · 22.1%High 10 · 2.5%

Intervention not reported

Global impression of recovery Global Perceived Effect Scale: scale from ‐5 to +5 (greater recovery) · patients with low back pain

The intervention showed no clear difference in global impression of recovery Global Perceived Effect Scale: scale… (low certainty).

1 finding from 1 review

Spinal manipulative therapy vs inert interventions

Recovery at one month · adults with chronic low‐back pain

It is very uncertain whether spinal manipulative therapy changes recovery at 1 month compared with inert interventions (very low certainty).

2 findings from 1 review

Comparison 1: community‐based antibiotic delivery vs usual care

Early neonatal mortality · neonates with sepsis

Comparison 1: community‐based antibiotic delivery probably leads to lower early neonatal mortality compared with standard care (moderate certainty).

1 finding from 1 review

Comparison 1: community‐based antibiotic delivery vs usual care

Late neonatal mortality · neonates with sepsis

Comparison 1: community‐based antibiotic delivery probably leads to lower late neonatal mortality compared with standard care (moderate certainty).

1 finding from 1 review

Comparison 1: community‐based antibiotic delivery vs usual care

Sepsis‐specific mortality · neonates with sepsis

Comparison 1: community‐based antibiotic delivery showed no clear difference in sepsis‐specific mortality compared with standard care (low certainty).

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 2 days oral amoxicillin + injectable gentamicin… showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Early neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Late neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Sepsis‐specific neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Treatment failure · neonates with possible serious bacterial infection

Comparison 2: 2 days oral amoxicillin + injectable gentamicin… showed no clear difference in treatment failure compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 2 days injectable benzylpenicillin + injectable… showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (low certainty).

1 finding from 1 review