Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

210 questions · 219 findings · 12 reviews · Schizophrenia

No studies found 37 · 16.9%GRADE not reported 16 · 7.3%Very low 60 · 27.4%Low 44 · 20.1%Moderate 53 · 24.2%High 9 · 4.1%

CHLORPROMAZINE vs OLANZAPINE

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

It is very uncertain whether CHLORPROMAZINE changes adverse effects: any observed extrapyramidal symptoms ‐ short term… compared with OLANZAPINE (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs RISPERIDONE

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

It is very uncertain whether CHLORPROMAZINE changes adverse effects: any observed extrapyramidal symptoms ‐ short term… compared with RISPERIDONE (very low certainty).

1 finding from 1 review

FLUPHENAZINE (ORAL) vs QUETIAPINE

Clinically important response (defined by study) ‐ short term (up to 12 weeks) decreased rate of BPRS score < 20% · patients with schizophrenia

It is very uncertain whether FLUPHENAZINE (ORAL) changes clinically important response (defined by study) ‐ short term (up to… compared with QUETIAPINE (very low certainty).

1 finding from 1 review