What do systematic reviews say?

First‐line thiazides vs calcium channel blockers

First‐line thiazides may leads to lower withdrawals due to adverse effects Duration: 1 to 5 years compared with first‐line calcium channel blockers (low certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.81 [0.75, 0.88]
  7 studies · 33908 participants
  Low

First‐line thiazides vs ACE inhibitor

First‐line thiazides showed no clear difference in total mortality Duration: 1 to 5 years compared with first‐line ACE inhibitors (moderate certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 1 [0.95, 1.07]
  3 studies · 30961 participants
  Moderate

First‐line thiazides vs ACE inhibitor

The review found no eligible studies for this question.

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

First‐line thiazides vs ACE inhibitor

First‐line thiazides showed no clear difference in total cardiovascular events Duration: 2.6 to 5 years compared with first‐line ACE inhibitors (low certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.97 [0.92, 1.02]
  3 studies · 30900 participants
  Low

First‐line thiazides vs ACE inhibitor

First‐line thiazides probably leads to lower total stroke Duration: 2.6 to 5 years compared with first‐line ACE inhibitors (moderate certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.89 [0.8, 0.99]
  3 studies · 30900 participants
  Moderate

First‐line thiazides vs ACE inhibitor

First‐line thiazides showed no clear difference in total CHD Duration: 2.6 to 5 years compared with first‐line ACE inhibitors (moderate certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 1.03 [0.96, 1.12]
  3 studies · 30900 participants
  Moderate

First‐line thiazides vs beta‐blocker

The review found no eligible studies for this question.

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

First‐line thiazides vs ACE inhibitor

First‐line thiazides showed no clear difference in total congestive heart failure Duration: 4 to 5 years compared with first‐line ACE inhibitors (moderate certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.94 [0.84, 1.04]
  2 studies · 30392 participants
  Moderate

First‐line thiazides vs ACE inhibitor

First‐line thiazides probably leads to lower withdrawals due to adverse effects Duration: 1 to 5 years compared with first‐line ACE inhibitors (moderate certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.73 [0.64, 0.84]
  3 studies · 25254 participants
  Moderate

First‐line thiazides vs alpha‐blocker

First‐line thiazides showed no clear difference in total mortality Duration: 3.2 years compared with first‐line alpha‐blockers (moderate certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.98 [0.88, 1.09]
  1 study · 24316 participants
  Moderate

First‐line thiazides vs alpha‐blocker

The review found no eligible studies for this question.

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

First‐line thiazides vs alpha‐blocker

First‐line thiazides probably leads to lower total cardiovascular events Duration: 3 to 3.2 years compared with first‐line alpha‐blockers (moderate certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.74 [0.69, 0.8]
  2 studies · 24396 participants
  Moderate

First‐line thiazides vs alpha‐blocker

First‐line thiazides showed no clear difference in total stroke Duration: 3 to 3.2 years compared with first‐line alpha‐blockers (moderate certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.86 [0.73, 1.01]
  2 studies · 24396 participants
  Moderate

First‐line thiazides vs alpha‐blocker

First‐line thiazides showed no clear difference in total CHD Duration: 3 to 3.2 years compared with first‐line alpha‐blockers (low certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.98 [0.86, 1.11]
  2 studies · 24396 participants
  Low

First‐line thiazides vs alpha‐blocker

First‐line thiazides probably leads to lower total congestive heart failure Duration: 3.2 years compared with first‐line alpha‐blockers (moderate certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.51 [0.45, 0.58]
  1 study · 24316 participants
  Moderate

First‐line thiazides vs alpha‐blocker

First‐line thiazides may leads to lower withdrawals due to adverse effects Duration: 1 to 3.2 years compared with first‐line alpha‐blockers (low certainty).

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  RR 0.7 [0.54, 0.89]
  3 studies · 24772 participants
  Low

First‐line thiazides vs beta‐blocker

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 18135 participants
  Moderate

First‐line thiazides vs beta‐blocker

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 18135 participants
  Low

First‐line thiazides vs beta‐blocker

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 18135 participants
  Low

First‐line thiazides vs beta‐blocker

• First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 6569 participants
  Low