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Evidence found and GRADE certainty

377 questions · 736 findings · 60 reviews · Dental caries

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No studies found 17 · 2.3%GRADE not reported 563 · 76.5%Very low 39 · 5.3%Low 47 · 6.4%Moderate 50 · 6.8%High 20 · 2.7%

1700 to 2200 ppm F toothpaste vs 250 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1700 to 2200 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with 250 ppm F toothpaste (low certainty).

1 finding from 1 review

2400 to 2800 ppm F toothpaste vs 440 to 550 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

2400 to 2800 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with 440 to 550 ppm F toothpaste (low certainty).

1 finding from 1 review

1450 to 1500 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1450 to 1500 ppm F toothpaste probably leads to lower caries increment, surface index D(M)FS compared with 1000 to 1250 ppm F toothpaste (moderate certainty).

1 finding from 1 review

440 to 550 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

440 to 550 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).

1 finding from 1 review

CPP-ACP vs No active treatment (control)

Average enamel surface roughness · Extracted human teeth with early/artificial enamel lesions (in vitro)

In vitro, CPP-ACP markedly reduced enamel surface roughness versus control (SMD -8.21, 95% CI -10.37 to -6.04; ungraded).

1 finding from 1 review

1450 to 1500 ppm F toothpaste vs 250 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1450 to 1500 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with 250 ppm F toothpaste (low certainty).

1 finding from 1 review

1000 to 1250 ppm F toothpaste vs 440 to 550 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1000 to 1250 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 440 to 550 ppm F toothpaste (low certainty).

1 finding from 1 review

1000 or 1100 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, surface index D(M)FS · Adults with mature permanent dentition (aged 18 to 93 years at study start)

1000 or 1100 ppm F toothpaste probably leads to lower caries increment, surface index DMFS compared with non-fluoride (0 ppm F) placebo toothpaste (moderate certainty).

1 finding from 1 review

1450 to 1500 ppm F toothpaste vs 440 to 550 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1450 to 1500 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with 440 to 550 ppm F toothpaste (low certainty).

1 finding from 1 review

1700 to 2200 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1700 to 2200 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 1000 to 1250 ppm F toothpaste (low certainty).

1 finding from 1 review

1700 to 2200 ppm F toothpaste vs 440 to 550 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1700 to 2200 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 440 to 550 ppm F toothpaste (low certainty).

1 finding from 1 review

2400 to 2800 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

2400 to 2800 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).

1 finding from 1 review

1000 to 1250 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1000 to 1250 ppm F toothpaste leads to lower caries increment, surface index D(M)FS compared with non-fluoride (0 ppm F) placebo toothpaste (high certainty).

1 finding from 1 review

2400 to 2800 ppm F toothpaste vs 1450 to 1500 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

2400 to 2800 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 1450 to 1500 ppm F toothpaste (moderate certainty).

1 finding from 1 review

440 to 550 ppm F toothpaste vs 250 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

440 to 550 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 250 ppm F toothpaste (low certainty).

1 finding from 1 review

Women who experienced preterm birth vs Women who did not experience preterm birth (term)

Decayed, missing, filled surfaces (DMFS) · pregnant women

Women who experienced preterm birth did not have a significantly different DMFS than those who did not (mean difference -0.15, 95% CI -3.40 to 3.09; 3 studies; I2=89%); certainty of evidence not graded.

1 finding from 1 review
  • Dental caries and preterm birth: a systematic review and meta-analysis. 2018 All outcomes
    Pregnant women assessed around delivery in observational studies across multiple countries (Mexico, Malawi, India, France, Jordan, Finland, Tanzania); mostly retrospective cohort and case-control designs
    MD -0.15 [-3.40, 3.09]
    3 studies · 2594 participants
    GRADE not reported

Fluorides combined with CPP-ACP vs Fluorides alone (monotherapy)

Total lesion area divided by total surface area (visual) · Patients with early caries lesions in permanent teeth (non-fluoridated water area)

Adding CPP-ACP to fluorides did not significantly change the lesion-area outcome for smooth-surface early caries lesions versus fluorides alone; not GRADE-rated.

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Filled primary surfaces at 3 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

Fluoride supplementation (tablets, drops, lozenges or chewing gum) showed no clear difference in filled primary surfaces at 5 years compared with placebo or no treatment; GRADE not reported.

2 findings from 1 review

Resin-based fissure sealant (2nd/3rd/4th generation) vs No sealant (control/no treatment)

Caries on occlusal surfaces of permanent molars (12 months) · Children and adolescents (general population, aged under 20 years)

Resin-based fissure sealant (2nd/3rd/4th generation) led to lower caries on occlusal surfaces of permanent molars (36 months) compared with no sealant (control/no treatment); GRADE not reported.

3 findings from 1 review