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Evidence found and GRADE certainty

174 questions · 184 findings · 7 reviews · Metabolic and Endocrine Disorders

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No studies found 56 · 30.4%GRADE not reported 2 · 1.1%Very low 51 · 27.7%Low 62 · 33.7%Moderate 13 · 7.1%High 0 · 0%

Summary of findings: pioglitazone monotherapy vs another pharmacological glucose‐lowering monotherapy

Metformin Diagnostic criteria: 2 studies applied the WHO 1999 criteria for 'prediabetes' (FPG > 6.1 mmol/L and < 7.0 mmol/L and/or a 2‐h glucose < 11.1 mmol/L after a 75 g OGTT; Chen 2007a; Zeng 2013) · people at increased risk for developing type 2 diabetes

Summary of findings: pioglitazone monotherapy showed no clear difference in metformin Diagnostic criteria: 2 studies applied the WHO 1999… compared with another pharmacological glucose‐lowering monotherapy (low certainty).

1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs another pharmacological glucose‐lowering monotherapy

Acarbose Diagnostic criteria: 1 study applied the WHO 1999 criteria for prediabetes (FPG > 6.1 mmol/L and < 7.0 mmol/L and/or a 2‐h glucose < 11.1 mmol/L after a 75 g OGTT; Chen 2007a) · people at increased risk for developing type 2 diabetes
1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs another pharmacological glucose‐lowering monotherapy

Repaglinide Diagnostic criteria: 1 study applied the ADA 2010 criteria (FPG ≥ 5.6 mmol/L and < 6.9 mmol/L and 2‐h glucose ≥ 7.8 mmol/L or < 11.0 mmol/L after a 75 g OGTT; Zhang 2007) · people at increased risk for developing type 2 diabetes
1 finding from 1 review

Summary of findings table for metformin plus intensive diet and exercise vs intensive diet and exercise

Development of type 2 diabetes · people at increased risk for developing type 2 diabetes

It is very uncertain whether summary of findings table for metformin plus intensive diet and… changes incidence of type 2 diabetes mellitus (N) Diagnostic criteria: 2… compared with intensive diet and exercise (very low certainty).

1 finding from 1 review