Adverse events · patients with acute asthma
Intramuscular corticosteroids showed no clear difference in adverse events compared with oral corticosteroids (low certainty).
1 finding from 1 review
Health outcomes Peak expiratory flow readings (higher readings indicate better peak flow) · patients with acute asthma
1 finding from 1 review
Persistence of symptoms · patients with acute asthma
Intramuscular corticosteroids showed no clear difference in symptom persistence compared with oral corticosteroids (low certainty).
1 finding from 1 review
24‐hour beta agonist use · patients with acute asthma
Intramuscular corticosteroids showed no clear difference in 24‐hour beta agonist use compared with oral corticosteroids (low certainty).
1 finding from 1 review
Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)
Oral steroids showed no clear difference in hearing ‐ return to normal hearing compared with placebo (moderate certainty).
1 finding from 1 review
RR 1.14 [0.97, 1.33]
Studies not reported
Moderate
Disease‐specific quality of life · children aged 6 months to 12 years with otitis media with effusion (OME)
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)
Oral steroids may leads to lower presence/persistence of OME compared with placebo (low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Adverse event: systemic corticosteroid side effects · children aged 6 months to 12 years with otitis media with effusion (OME)
It is very uncertain whether oral steroids changes adverse event: systemic corticosteroid side effects compared with placebo (very low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Hearing · children aged 6 months to 12 years with otitis media with effusion (OME)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Disease‐specific quality of life · children aged 6 months to 12 years with otitis media with effusion (OME)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)
Oral steroids showed no clear difference in presence/persistence of OME (3 to 9 months ‐ medium‐term) № of… compared with no treatment (low certainty).
1 finding from 1 review
RR 1.02 [0.89, 1.17]
Studies not reported
Low
Adverse event: systemic corticosteroid side effects · children aged 6 months to 12 years with otitis media with effusion (OME)
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Low birthweight · pregnant women
Mild/moderate topical corticosteroids may leads to lower low birth weight compared with no topical corticosteroids (low certainty).
1 finding from 1 review
RR 0.9
55713 participants
Low
Preterm birth · pregnant women
Mild/moderate topical corticosteroids may leads to lower preterm delivery compared with no topical corticosteroids (low certainty).
1 finding from 1 review
RR 0.88
55713 participants
Low
Foetal death · pregnant women
Mild/moderate topical corticosteroids may leads to lower foetal death compared with no topical corticosteroids (low certainty).
1 finding from 1 review
RR 0.7
48749 participants
Low
Low Apgar score · pregnant women
Mild/moderate topical corticosteroids may leads to lower low Apgar score compared with no topical corticosteroids (low certainty).
1 finding from 1 review
RR 0.73
8756 participants
Low
Congenital abnormality · pregnant women
Mild/moderate topical corticosteroids may leads to lower congenital abnormality compared with no topical corticosteroids (low certainty).
1 finding from 1 review
RR 0.93
9263 participants
Low
Orofacial cleft · pregnant women
Mild/moderate topical corticosteroids may leads to lower orofacial cleft compared with no topical corticosteroids (low certainty).
1 finding from 1 review
RR 0.95
38446 participants
Low
Congenital abnormality · pregnant women
Potent/very potent topical corticosteroids may leads to lower congenital abnormality compared with no topical corticosteroids (low certainty).
1 finding from 1 review
RR 0.56
9342 participants
Low
Orofacial cleft · pregnant women
Potent/very potent topical corticosteroids may leads to higher orofacial cleft compared with no topical corticosteroids (low certainty).
1 finding from 1 review
RR 1.5
36348 participants
Low