Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

251 questions · 255 findings · 24 reviews

No studies found 61 · 23.9%GRADE not reported 40 · 15.7%Very low 45 · 17.6%Low 56 · 22%Moderate 38 · 14.9%High 15 · 5.9%

Mycophenolate mofetil vs methotrexate

Incidence of narcotic use for pain control · people receiving allogeneic hematopoietic stem cell transplantation

Mycophenolate mofetil may leads to lower incidence of narcotic use for pain control compared with methotrexate (low certainty).

1 finding from 1 review

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Overall survival at 5‐year · women with early poor prognosis breast cancer

High‐dose chemotherapy showed no clear difference in overall survival at 5‐year compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Event‐free survival · women with early poor prognosis breast cancer

High‐dose chemotherapy showed no clear difference in event‐free survival at 5‐year compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Treatment‐related mortality · women with early poor prognosis breast cancer

High‐dose chemotherapy leads to higher treatment‐related mortality compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Second cancers at 4 ‐ 9‐year median · women with early poor prognosis breast cancer

High‐dose chemotherapy showed no clear difference in second cancers at 4 ‐ 9‐year median compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

Ursodeoxycholic acid vs placebo or no treatment

Incidence of hepatic veno‐occlusive disease ( · Patients undergoing stem cell transplant with malignant and non‐malignant diseases

Summary of findings: Ursodeoxycholic acid may leads to lower incidence of hepatic veno‐occlusive disease ( compared with placebo or no treatment (low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no treatment

Incidence of hepatic veno‐occlusive disease ( · People undergoing stem cell transplant with malignant diseases

It is very uncertain whether summary of findings: Low molecular weight heparin changes incidence of hepatic veno‐occlusive disease ( compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no treatment

Frequency of adverse events ( · People undergoing stem cell transplant with malignant diseases

It is very uncertain whether summary of findings: Low molecular weight heparin changes frequency of adverse events ( compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Summary of findings: Defibrotide vs no treatment

Incidence of hepatic veno‐occlusive disease ( · Children undergoing stem cell transplant with malignant and non‐malignant diseases and risk factors for hepatic veno‐occlusive disease

Summary of findings: Defibrotide showed no clear difference in incidence of hepatic veno‐occlusive disease ( compared with no treatment (low certainty).

1 finding from 1 review

Ursodeoxycholic acid vs placebo or no treatment

Overall survival ( · Patients undergoing stem cell transplant with malignant and non‐malignant diseases

Summary of findings: Ursodeoxycholic acid showed no clear difference in overall survival ( compared with placebo or no treatment (low certainty).

1 finding from 1 review

Summary of findings: Defibrotide vs no treatment

Overall survival ( · Children undergoing stem cell transplant with malignant and non‐malignant diseases and risk factors for hepatic veno‐occlusive disease

Summary of findings: Defibrotide showed no clear difference in overall survival ( compared with no treatment (low certainty).

1 finding from 1 review

Summary of findings: Defibrotide vs no treatment

All‐cause mortality at 100 days post‐transplant · Children undergoing stem cell transplant with malignant and non‐malignant diseases and risk factors for hepatic veno‐occlusive disease

Summary of findings: Defibrotide showed no clear difference in all‐cause mortality at 100 days post‐transplant ( compared with no treatment (low certainty).

1 finding from 1 review

Summary of findings: Defibrotide vs no treatment

Mortality attributable to hepatic veno‐occlusive disease ( · Children undergoing stem cell transplant with malignant and non‐malignant diseases and risk factors for hepatic veno‐occlusive disease

Summary of findings: Defibrotide showed no clear difference in mortality attributable to hepatic veno‐occlusive disease ( compared with no treatment (low certainty).

1 finding from 1 review