Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

444 questions · 453 findings · 34 reviews · Headline outcomes only

No studies found 117 · 25.8%GRADE not reported 17 · 3.8%Very low 176 · 38.9%Low 96 · 21.2%Moderate 34 · 7.5%High 13 · 2.9%

ARIPIPRAZOLE (IM) vs haloperidol

Repeated need for tranquillisation ‐ needing additional injections during 24 hours · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether ARIPIPRAZOLE (IM) changes repeated need for tranquillisation ‐ needing additional injections… compared with OTHER ANTIPSYCHOTIC: a. HALOPERIDOL (very low certainty).

1 finding from 1 review

ARIPIPRAZOLE (IM) vs haloperidol

Specific behaviour: Agitation ‐ clinically important change (PANSS ‐EC reduction ≥ 40% from baseline) ‐ up to 2 hours · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether ARIPIPRAZOLE (IM) changes specific behaviour: Agitation ‐ clinically important change (PANSS… compared with OTHER ANTIPSYCHOTIC: a. HALOPERIDOL (very low certainty).

1 finding from 1 review

RISPERIDONE vs OLANZAPINE

Global outcome: need for additional measures · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether RISPERIDONE changes global outcome: need for additional measures compared with OTHER ANTIPSYCHOTIC: b. OLANZAPINE (very low certainty).

1 finding from 1 review

RISPERIDONE vs QUETIAPINE

Adverse effects ‐ movement disorders · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether RISPERIDONE changes adverse effects: movement disorders over 24 hours compared with OTHER ANTIPSYCHOTIC: c. QUETIAPINE (very low certainty).

1 finding from 1 review

RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE

Adverse effects ‐ movement disorders · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether RISPERIDONE changes adverse effects: movement disorders, over 24 hours compared with COMBINATION: a. RISPERIDONE + OXCARBAZEPINE (very low certainty).

1 finding from 1 review