Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

162 questions · 167 findings · 24 reviews · Musculoskeletal

No studies found 65 · 38.9%GRADE not reported 6 · 3.6%Very low 24 · 14.4%Low 55 · 32.9%Moderate 16 · 9.6%High 1 · 0.6%

Cyclophosphamide vs methylprednisolone

Response to treatment (20% improvement)* · patients with neuropsychiatric involvement in systemic lupus erythematosus

It is very uncertain whether cyclophosphamide changes response to treatment (20% improvement)* compared with methylprednisolone (very low certainty).

1 finding from 1 review

Cyclophosphamide vs methylprednisolone

Urinary tract infection · patients with neuropsychiatric involvement in systemic lupus erythematosus

It is very uncertain whether cyclophosphamide changes adverse events ‐ Urinary tract infections compared with methylprednisolone (very low certainty).

1 finding from 1 review

Cyclophosphamide vs methylprednisolone

Adverse events ‐ Death · patients with neuropsychiatric involvement in systemic lupus erythematosus

It is very uncertain whether cyclophosphamide changes adverse events ‐ Death compared with methylprednisolone (very low certainty).

1 finding from 1 review