Exposed bone (present versus absent) · Adults (>18 years) with established dry socket following permanent tooth extraction
1 finding from 1 review
PRGF versus Alvogyl (King 2018), exposed bone (% patients): day 3 PRGF 9.1% vs Alvogyl 9.1%; day 7 PRGF 0% vs Alvogyl 22.7% (P<0.05 at day 7)
1 study · 44 participants
GRADE not reported
Pain (VAS cm) · Adults (>18 years) with established dry socket following permanent tooth extraction
Plasma rich in growth factors (PRGF) showed no clear difference in pain (VAS cm) compared with alvogyl; GRADE not reported.
1 finding from 1 review
Pain (VAS cm) · Adults (>18 years) with established dry socket following permanent tooth extraction
Advanced platelet rich fibrin (A-PRF) led to lower pain (VAS cm) compared with control (no treatment); GRADE not reported.
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
2 findings from 1 review
No clinical failure in any participant (Malekafzali 2011); not estimable
1 study · 80 participants
GRADE not reported
RR 3.00 [0.13, 69.70]
1 study · 42 participants
Very low
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
2 findings from 1 review
No radiological failure in any participant at 6 months; not estimable
1 study · 42 participants
Very low
RR 0.33 [0.04, 2.94]
1 study · 80 participants
GRADE not reported
Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year
1 finding from 1 review
Healing of MRONJ · People with established (manifest) MRONJ
It is very uncertain whether platelet-rich fibrin after bone surgery changes healing of MRONJ (mucosal integrity and absence of infection) compared with bone surgery alone (very low certainty).
1 finding from 1 review
Healing of MRONJ (mucosal integrity, absence of infection, and no re-intervention) · People with established (manifest) MRONJ
It is very uncertain whether platelet-rich fibrin after bone surgery changes healing of MRONJ (mucosal integrity, absence of infection, and no… compared with bone surgery alone (very low certainty).
1 finding from 1 review
Tooth survival · People with avulsed and replanted permanent (front) teeth
It is very uncertain whether hyperbaric oxygen (following replantation) changes tooth survival at 12 months compared with control (very low certainty).
1 finding from 1 review
Adverse effects · People with avulsed and replanted permanent (front) teeth
1 finding from 1 review
Pulpal healing at 12 months · People with avulsed and replanted permanent (front) teeth
It is very uncertain whether hyperbaric oxygen (following replantation) changes pulpal healing at 12 months compared with control (very low certainty).
1 finding from 1 review
Periodontal healing at 12 months · People with avulsed and replanted permanent (front) teeth
It is very uncertain whether hyperbaric oxygen (following replantation) changes periodontal healing at 12 months compared with control (very low certainty).
1 finding from 1 review
Postoperative pain (VAS 0-100) - 1 day · People requiring retreatment of periapical lesions (failed root canal therapy)
Plasma rich in growth factors (PRGF) graft may leads to lower postoperative pain (VAS 0-100) - 1 day compared with no grafting (low certainty).
1 finding from 1 review
Complications · Patients with insufficient bone below the maxillary sinus requiring dental implants
1 finding from 1 review
Raghoebar 2005: 1 complication in the non-PRP arm, OR 0.27 (0.01 to 8.46), P = 0.46; Torres 2009 (PRP only = 3, no-PRP only = 2), OR 1.49 (0.15 to 15.07), P = 1.00. No statistically significant difference.
2 studies · 62 participants
GRADE not reported
Implant failure · Patients with insufficient bone below the maxillary sinus requiring dental implants
1 finding from 1 review
No statistically significant difference for implant failures. Per trial: Raghoebar 2005 1 failure in the PRP arm, OR 3.67 (0.12 to 113.73), P = 0.46; Torres 2009 (PRP only = 1, no-PRP only = 2), OR 0.50 (0.01 to…
2 studies · 62 participants
GRADE not reported
Partial graft loss · Patients with insufficient bone below the maxillary sinus requiring dental implants
Bone graft with platelet-rich plasma (PRP) showed no clear difference in partial graft loss compared with bone graft without PRP; GRADE not reported.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
CEM and calcium hydroxide did not differ significantly in pulpotomy success (indirect comparison); ungraded.
1 finding from 1 review
Prefabricated metal post and core (Category II) vs Metal custom-cast post and core (Category I)
Outcome not reported · Participants with permanent endodontically-treated (root-filled) teeth for which a post is indicated to retain the final restoration
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
The review found no eligible studies for this question.
1 finding from 1 review
Acceptance of LA · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
The review found no eligible studies for this question.
1 finding from 1 review