Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

93 questions · 97 findings · 7 reviews

No studies found 25 · 25.8%GRADE not reported 16 · 16.5%Very low 21 · 21.6%Low 22 · 22.7%Moderate 11 · 11.3%High 2 · 2.1%

Thrombopoietin mimetics vs placebo or usual care

Number of participants with severe or life‐threatening bleeding · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

It is very uncertain whether thrombopoietin mimetics changes number of participants with severe or life‐threatening bleeding compared with placebo or standard care (very low certainty).

1 finding from 1 review

Intervention not reported

Number of participants with at least 1 bleeding episode · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

It is very uncertain whether the intervention changes number of participants with at least 1 bleeding episode (very low certainty).

1 finding from 1 review

Thrombopoietin mimetics vs placebo

Number of participants with at least 1 bleeding episode · People with chronic bone marrow failure

Thrombopoietin mimetic showed no clear difference in number of participants with at least one bleeding episode compared with placebo (low certainty).

1 finding from 1 review

Thrombopoietin mimetics vs placebo

Number of participants with severe or life‐threatening bleeding · People with chronic bone marrow failure

Thrombopoietin mimetic showed no clear difference in number of participants with at least one severe or life‐threatening… compared with placebo (low certainty).

1 finding from 1 review