Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

458 questions · 466 findings · 48 reviews · Schizophrenia

No studies found 87 · 18.7%GRADE not reported 82 · 17.6%Very low 153 · 32.8%Low 111 · 23.8%Moderate 19 · 4.1%High 14 · 3%

HALOPERIDOL vs placebo

Leaving the study early · patients with schizophrenia

HALOPERIDOL showed no clear difference in leaving the study early compared with PLACEBO (moderate certainty).

1 finding from 1 review

HALOPERIDOL vs placebo

Adverse effects. Specific: movement disorders ‐ parkinsonism · patients with schizophrenia

HALOPERIDOL probably leads to higher adverse effects: Movement disorders ‐ parkinsonism compared with PLACEBO (moderate certainty).

1 finding from 1 review

α‐FLUPENTHIXOL vs PLACEBO or β‐FLUPENTHIXOL

Global state: clinically important change in global state needing additional medication ‐ chlorpromazine · patients with schizophrenia

It is very uncertain whether α‐FLUPENTHIXOL changes global state: clinically important change in global state needing… compared with PLACEBO or β‐FLUPENTHIXOL (very low certainty).

1 finding from 1 review

α‐FLUPENTHIXOL vs PLACEBO or β‐FLUPENTHIXOL

General functioning: Poor social functioning ‐ modified Cooper's ratings5,6 · patients with schizophrenia

It is very uncertain whether α‐FLUPENTHIXOL changes general functioning: Poor social functioning ‐ modified Cooper's… compared with PLACEBO or β‐FLUPENTHIXOL (very low certainty).

1 finding from 1 review