Depression · People with temporomandibular disorders (TMD)
Occlusal splint led to lower depression compared with no treatment or placebo (non-occlusal or transparent-foil placebo…; GRADE not reported.
1 finding from 1 review
Change in probing pocket depth (PPD) · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after… showed no clear difference in change in probing depth (PD/PPD) compared with submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT; GRADE not reported.
1 finding from 1 review
Difficulty in speech (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Antioxidants (lycopene, curcumin, Oxitard) showed no clear difference in difficulty in speech (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.
1 finding from 1 review
Lactobacillus count (CFU/mL) · Children and/or adolescents (<18 years) without background systemic disease
Probiotics may make little to no difference to Lactobacillus count versus control (MD -0.78 CFU/mL, 95%CI -1.65 to 0.09; very low certainty).
1 finding from 1 review
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after submucosal instrumentation (SI) vs Submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT
Outcome not reported · Adults (> 18 years) with peri-implantitis, receiving supportive treatment
The review found no eligible studies for this question.
1 finding from 1 review
Analgesic (painkiller) use · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
Single preoperative dose of systemic antibiotics (clindamycin 600… showed no clear difference in analgesic use compared with matched placebo, total chemo-mechanical debridement and root filling; GRADE not reported.
1 finding from 1 review
Patient satisfaction · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
The review found no eligible studies for this question.
1 finding from 1 review
Percussion pain at 7 days · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
Postoperative systemic antibiotics… showed no clear difference in percussion pain at 7 days compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
1 finding from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether intralesional dexamethasone injections changes maximal mouth opening (interincisal distance) compared with placebo injections (very low certainty).
2 findings from 1 review
Quality of life · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
The review found no eligible studies for this question.
1 finding from 1 review
Any adverse effect related to aPDT · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
The review found no eligible studies for this question.
1 finding from 1 review
Salivary pH · Children and/or adolescents (<18 years) without background systemic disease
Probiotics may make little to no difference to salivary pH versus control (MD -0.12 pH units, 95%CI -0.72 to 0.48; very low certainty).
1 finding from 1 review
Adverse effects · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
1 finding from 1 review
Frequency of joint noise · People with temporomandibular disorders (TMD)
It is very uncertain whether occlusal splint changes frequency of joint noise compared with no treatment or placebo (non-occlusal or transparent-foil placebo… (very low certainty).
1 finding from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether pentoxifylline changes maximal mouth opening (interincisal distance) compared with placebo or no active treatment (very low certainty).
2 findings from 1 review
Dental caries in children · Children and/or adolescents (<18 years) without background systemic disease
Probiotics probably make little to no difference to the number of dental caries versus control (MD -0.24 carious pieces, 95%CI -0.72 to 0.23; low certainty).
1 finding from 1 review
Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two trials, SDF markedly increased individual-level caries arrestment versus placebo (OR 18.10; ungraded subgroup).
1 finding from 1 review
Participant satisfaction · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
The review found no eligible studies for this question.
1 finding from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
Goel 2015 (3-arm: intralesional betamethasone vs lycopene vs placebo, 90 per arm): appeared to show increased interincisal distance in both intervention groups vs placebo, but only between-group differences with no…
1 study · 180 participants
GRADE not reported
Pain at 72 hours · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
1 finding from 1 review
The median pain at 72 hours in the control group was 0 (range 0 to 10); the median pain at 72 hours in the intervention group was the same (median 0, range 0 to 7). P = 0.116 (Mann-Whitney U).
1 study · 72 participants
Low