Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

107 questions · 107 findings · 13 reviews · Anaesthesia

No studies found 16 · 15%GRADE not reported 9 · 8.4%Very low 43 · 40.2%Low 32 · 29.9%Moderate 6 · 5.6%High 1 · 0.9%

Epidural analgesia vs systemic analgesia

Atrial fibrillation or atrial flutter (0 to 2 weeks) · adult cardiac surgical patients

Epidural analgesia showed no clear difference in atrial fibrillation or atrial flutter (0 to 2 weeks) compared with systemic analgesia (moderate certainty).

1 finding from 1 review

Inhaled NO vs placebo or conventional therapy

Mortality before hospital discharge · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

It is very uncertain whether inhaled nitric oxide changes mortality prior to discharge1 compared with placebo or conventional therapy (very low certainty).

1 finding from 1 review

Preoperative inspiratory muscle training vs usual care, non‐exercise intervention

Postoperative atelectasis original authors’ definitions · adult participants undergoing cardiac and major abdominal surgery

Preoperative inspiratory muscle training may leads to lower postoperative atelectasis original authors’ definitions compared with usual care, non‐exercise intervention (low certainty).

1 finding from 1 review

Preoperative inspiratory muscle training vs usual care, non‐exercise intervention

Postoperative pneumonia original authors’ definitions · adult participants undergoing cardiac and major abdominal surgery

Preoperative inspiratory muscle training probably leads to lower postoperative pneumonia original authors’ definitions compared with usual care, non‐exercise intervention (moderate certainty).

1 finding from 1 review

Preoperative inspiratory muscle training vs usual care, non‐exercise intervention

Mechanical ventilation > 48 hours · adult participants undergoing cardiac and major abdominal surgery

It is very uncertain whether preoperative inspiratory muscle training changes mechanical ventilation > 48 hours compared with usual care, non‐exercise intervention (very low certainty).

1 finding from 1 review

Preoperative inspiratory muscle training vs usual care, non‐exercise intervention

Mortality In the early postoperative period (≤ 30 days) · adult participants undergoing cardiac and major abdominal surgery

It is very uncertain whether preoperative inspiratory muscle training changes all‐cause mortality within 30 days during postoperative period compared with usual care, non‐exercise intervention (very low certainty).

1 finding from 1 review