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Evidence found and GRADE certainty

140 questions · 145 findings · 33 reviews · Common Mental Disorders

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No studies found 19 · 13.1%GRADE not reported 1 · 0.7%Very low 53 · 36.6%Low 41 · 28.3%Moderate 25 · 17.2%High 6 · 4.1%

Lithium vs OLANZAPINE

Acceptability: total withdrawals · acute mania

Lithium may leads to higher acceptability: total withdrawals compared with olanzapine (low certainty).

1 finding from 1 review

Lithium vs placebo

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with placebo (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.76 [0.46, 1.25]
    7 studies · 1353 participants
    Moderate

Lithium vs chlorpromazine

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with chlorpromazine (low certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.75 [0.92, 3.31]
    2 studies · 262 participants
    Low

Lithium vs haloperidol

Acceptability: total withdrawals · acute mania

It is very uncertain whether lithium changes acceptability: total withdrawals compared with haloperidol (very low certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.29 [0.03, 3.12]
    1 study · 30 participants
    Very low

Lithium vs Zuclopenthixol (Cis Z/Trans E isomer)

Acceptability: total withdrawals · acute mania

It is very uncertain whether lithium changes acceptability: total withdrawals compared with zuclopenthixol (very low certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.78 [0.17, 3.49]
    1 study · 28 participants
    Very low

Lithium vs RISPERIDONE

Acceptability: total withdrawals · acute mania

Lithium probably leads to higher acceptability: total withdrawals compared with risperidone (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.85 [1.02, 3.34]
    3 studies · 255 participants
    Moderate

Lithium vs ARIPIPRAZOLE

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with aripiprazole (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.94 [0.6, 1.46]
    1 study · 315 participants
    Moderate

Lithium vs topiramate

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with topiramate (high certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.28 [0.66, 2.48]
    2 studies · 1352 participants
    High

Lithium vs clonazepam

Acceptability: total withdrawals · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs ECT

Acceptability: total withdrawals · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs all antimanic agents

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with all antimanic agents (high certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.16 [0.89, 1.52]
    24 studies · 4201 participants
    High

Valproate vs placebo

Dropout · Children and adolescents with acute mania

Valproate showed no clear difference in dropout rate ‐ All‐cause At 4‐6 weeks (secondary acceptability… compared with placebo (low certainty).

1 finding from 1 review

Valproate vs lithium

Dropout · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in dropout rate ‐ All‐cause At 2‐4 weeks (secondary acceptability… compared with lithium (moderate certainty).

1 finding from 1 review

Valproate vs lithium

Dropout · Children and adolescents with acute mania

It is very uncertain whether valproate changes dropout rate ‐ All‐cause At 8 weeks (secondary acceptability outcome) compared with lithium (very low certainty).

1 finding from 1 review

Valproate vs OLANZAPINE

Dropout · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in dropout rate ‐ All‐cause At 3‐12 weeks (secondary acceptability… compared with olanzapine (high certainty).

1 finding from 1 review

Valproate vs RISPERIDONE

Dropout · Children and adolescents with acute mania

Valproate showed no clear difference in dropout rate ‐ All‐cause (secondary acceptability outcome) At 5 ‐ 12… compared with risperidone (low certainty).

1 finding from 1 review

Valproate vs placebo

Dropout · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in dropout rate ‐ All‐cause 3‐8 weeks (secondary acceptability outcome) compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings: Specialist inpatient care for weight restoration vs active outpatient or combination brief hospital/outpatient care

Secondary outcome: acceptability of treatment · participants with anorexia nervosa

It is very uncertain whether summary of findings: Specialist inpatient care for weight restoration changes acceptability: number of participants who completed treatment (at… compared with active outpatient or combination brief hospital/outpatient care (very low certainty).

1 finding from 1 review

Stand‐alone couple or family therapy vs other structured or non‐specific intervention

Dropout · post‐traumatic stress disorder (PTSD)

Stand‐alone couple or family therapy showed no clear difference in treatment dropout (treatment acceptability) compared with other structured or non‐specific intervention (low certainty).

1 finding from 1 review

Adjunctive couple or family therapy vs structured or non‐specific individual therapy alone

Dropout · post‐traumatic stress disorder (PTSD)

Adjunctive couple or family therapy showed no clear difference in treatment dropout (treatment acceptability) compared with structured or non‐specific individual therapy alone (low certainty).

1 finding from 1 review