Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

737 questions · 750 findings · 76 reviews

No studies found 182 · 24.3%GRADE not reported 95 · 12.7%Very low 229 · 30.5%Low 128 · 17.1%Moderate 76 · 10.1%High 40 · 5.3%

Live zoster vaccine vs placebo

Participants with adverse events Clinical or laboratory criteria · healthy older adults aged ≥ 60 years

Live zoster vaccine probably leads to higher participants with adverse eventsClinical or laboratory criteria compared with placebo (moderate certainty).

1 finding from 1 review

Live zoster vaccine vs placebo

Systemic adverse events at · healthy older adults aged ≥ 60 years

Live zoster vaccine showed no clear difference in participants with adverse events ‐ systemic adverse eventsClinical… compared with placebo (moderate certainty).

1 finding from 1 review

Live zoster vaccine vs placebo

Participants with adverse events ‐ injection site adverse events Clinical criteria · healthy older adults aged ≥ 60 years

Live zoster vaccine probably leads to higher participants with adverse events ‐ injection site adverse… compared with placebo (moderate certainty).

1 finding from 1 review

Live zoster vaccine vs placebo

Dropouts Clinical or laboratory criteria · healthy older adults aged ≥ 60 years

Live zoster vaccine showed no clear difference in dropoutsClinical or laboratory criteria compared with placebo (moderate certainty).

1 finding from 1 review

Recombinant zoster vaccine vs placebo

Cumulative incidence of herpes zoster at least 3.2 years · healthy older adults aged ≥ 60 years

Recombinant zoster vaccine probably leads to lower cumulative incidence of herpes zoster at least 3.2 years compared with placebo (moderate certainty).

1 finding from 1 review

Recombinant zoster vaccine vs placebo

Participants with adverse events ‐ death Clinical criteria · healthy older adults aged ≥ 60 years

Recombinant zoster vaccine showed no clear difference in participants with adverse events ‐ deathClinical criteria compared with placebo (moderate certainty).

1 finding from 1 review

CBT interventions (CBT with and without exercise) vs control (standard care or sham treatments)

Falls · older adults (mean age minus 1 standard deviation is more than 60 years)

It is very uncertain whether CBT interventions (CBT with and without exercise) changes occurrence of falls compared with control (standard care or sham treatments) (very low certainty).

1 finding from 1 review

Intervention not reported

Pins (No direct evidence, indirect evidence only) · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether the intervention changes pins (No direct evidence, indirect evidence only) (very low certainty).

1 finding from 1 review

Intervention not reported

Screws (3 RCTs; 152 participants)a · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether the intervention changes screws (3 RCTs; 152 participants)a (very low certainty).

1 finding from 1 review

Intervention not reported

Non‐operative treatment (No direct evidence, indirect evidence only) · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether the intervention changes non‐operative treatment (No direct evidence, indirect evidence only) (very low certainty).

1 finding from 1 review