Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

104 questions · 104 findings · 11 reviews · Skin

No studies found 12 · 11.5%GRADE not reported 6 · 5.8%Very low 29 · 27.9%Low 28 · 26.9%Moderate 23 · 22.1%High 6 · 5.8%

Intervention not reported

Improvement in acne severity assessed by a decrease in total inflammatory lesion count, measured in participants who were treated for a minimum period of 16 weeks (Changes from baseline in total inflammatory lesion count and number of participants... · participants with moderate and severe acne
1 finding from 1 review

Intervention not reported

Frequency of serious adverse effects 20 to 24 weeks · participants with moderate and severe acne

It is very uncertain whether the intervention changes frequency of serious adverse effects 20 to 24 weeks (very low certainty).

1 finding from 1 review

Intervention not reported

Improvement in acne severity assessed by physician's global evaluation 20 to 24 weeks · participants with moderate and severe acne
1 finding from 1 review

MAL‐PDT vs red light only

Investigator's global assessment (IGA) of improvement Treatment 'success' as defined by IGA score decrease5 · Moderate and severe acne vulgaris

MAL‐PDT probably leads to higher investigator's global assessment (IGA) of improvement Treatment… compared with red light only (moderate certainty).

1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    RR 1.74 [1.11, 2.74]
    3 studies · 360 participants
    Moderate

ALA‐PDT vs blue light only

Participant's global assessment of improvement Non‐standardised scale5 · Moderate and severe acne vulgaris

ALA‐PDT showed no clear difference in participant's global assessment of improvement Non‐standardised scale5 compared with blue light only (low certainty).

1 finding from 1 review

ALA‐PDT vs blue light only

Investigator‐assessed change in inflamed lesions (ILs) Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    1 study · 266 participants
    Very low

ALA‐PDT vs blue light only

Investigator‐assessed percentage change in ILs Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    1 study · 266 participants
    Very low

ALA‐PDT vs blue light only

Investigator‐assessed severe adverse effects Application site blister · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    1 study · 266 participants
    Very low

ALA‐PDT vs blue light only

Investigator's global assessment (IGA) of improvement Treatment 'success' as defined by IGA score decrease5 · Moderate and severe acne vulgaris

ALA‐PDT showed no clear difference in investigator's global assessment (IGA) of improvement Treatment… compared with blue light only (low certainty).

1 finding from 1 review

MAL‐PDT vs red light only

Paticipant's global assessment of improvement ‐ Not measured · Moderate and severe acne vulgaris

The review found no eligible studies for this question.

1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

MAL‐PDT vs red light only

Investigator‐assessed change in inflamed lesions (ILs) Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate

MAL‐PDT vs red light only

Investigator‐assessed change in non‐inflamed lesions (NILs) Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate

MAL‐PDT vs red light only

Investigator‐assessed percentage change in ILs Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate

MAL‐PDT vs red light only

Investigator‐assessed percentage change in NILs Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate

MAL‐PDT vs red light only

Investigator‐assessed severe adverse effects Application site blister · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate

Azoles vs moderate‐potent corticosteroid/azole combinations

Clinical cure · patients with tinea cruris and tinea corporis

It is very uncertain whether azoles changes clinical cure (immediately at end of treatment) Resolution of… compared with moderate‐potent corticosteroid/azole combinations (very low certainty).

1 finding from 1 review