Summary of findings table ‐ Metformin + megestrol vs megestrol
Recurrence of endometrial hyperplasia · endometrial hyerplasia
1 finding from 1 review
- no estimate extracted1 study · 8 participantsVery low
Findings
What do systematic reviews say?
118 questions · 132 findings · 10 reviews · Gynaecology and Fertility
No studies found 30 · 22.7%GRADE not reported 3 · 2.3%Very low 47 · 35.6%Low 41 · 31.1%Moderate 11 · 8.3%High 0 · 0%
Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system
Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyperplasia
It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes regression of endometrial hyperplasia (with or without atypia) to… compared with levonorgestrel intrauterine system (very low certainty).
1 finding from 1 review
- OR 3.42 [0.13, 88.4]1 study · 46 participantsVery low
Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system
Recurrence of endometrial hyperplasia · endometrial hyperplasia
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system
Progression of endometrial hyperplasia to endometrial cancer · endometrial hyperplasia
1 finding from 1 review
- no estimate extracted1 study · 1 participantsVery low
Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system
Hysterectomy rate · endometrial hyperplasia
It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes hysterectomy rate compared with levonorgestrel intrauterine system (very low certainty).
1 finding from 1 review
- OR 0.12 [0.01, 1.95]1 study · 46 participantsVery low
Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system
Abnormal uterine bleeding · endometrial hyperplasia
It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes abnormal uterine bleeding compared with levonorgestrel intrauterine system (very low certainty).
1 finding from 1 review
- OR 0.61 [0.16, 2.27]1 study · 49 participantsVery low
Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system
Adverse effects during treatment ‐ all effects · endometrial hyperplasia
It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes adverse effects during treatment ‐ all effects compared with levonorgestrel intrauterine system (very low certainty).
1 finding from 1 review
- OR 4 [1.15, 13.9]1 study · 51 participantsVery low
Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system
Adverse events: nausea · endometrial hyperplasia
It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes adverse effects during treatment ‐ nausea compared with levonorgestrel intrauterine system (very low certainty).
1 finding from 1 review
- OR 5.11 [1.21, 21.68]1 study · 51 participantsVery low
Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system
Adverse effects during treatment ‐ heaviness in lower abdomen · endometrial hyperplasia
It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes adverse effects during treatment ‐ heaviness in lower abdomen compared with levonorgestrel intrauterine system (very low certainty).
1 finding from 1 review
- OR 1.38 [0.32, 5.85]1 study · 51 participantsVery low
Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system
Adverse effects during treatment ‐ pain in abdomen · endometrial hyperplasia
It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes adverse effects during treatment ‐ pain in abdomen compared with levonorgestrel intrauterine system (very low certainty).
1 finding from 1 review
- OR 0.83 [0.22, 3.18]1 study · 51 participantsVery low
Pharmacological interventions vs pharmacological intervention
Adverse events ‐ Metformin plus liraglutide vs metformin Nausea Diarrhoea Headache · obese women with subfertility
It is very uncertain whether pharmacological intervention changes adverse events ‐ Metformin plus liraglutide vs metformin Nausea… compared with pharmacological intervention (very low certainty).
1 finding from 1 review
- Pharmacological and non‐pharmacological strategies for obese women with subfertility 2021 · Cochrane Headline outcomes onlyOR 7.22 [0.72, 73]1 study · 28 participantsVery low
Pharmacological interventions vs pharmacological intervention
Clinical pregnancyMetformin plus liraglutide vs metformin Met + CC + L‐carnitine vs Met + CC + placebo · obese women with subfertility
It is very uncertain whether pharmacological intervention changes clinical pregnancyMetformin plus liraglutide vs metformin Met + CC +… compared with pharmacological intervention (very low certainty).
1 finding from 1 review
- Pharmacological and non‐pharmacological strategies for obese women with subfertility 2021 · Cochrane Headline outcomes onlyOR 5.2 [2.59, 10.4]1 study · 28 participantsVery low
Pharmacological interventions vs pharmacological intervention
Weight ‐ BMI changeMetformin plus liraglutide vs metformin Met + CC + L‐carnitine vs Met + CC + placebo Weight changeDexfenfluramine vs placebo Weight ‐ body fatMetformin plus liraglutide vs metformin · obese women with subfertility
1 finding from 1 review
- Pharmacological and non‐pharmacological strategies for obese women with subfertility 2021 · Cochrane Headline outcomes onlyno estimate extracted1 study · 28 participantsVery low
LOD vs medical interventions
Menstrual regularity at 12 months Laser LOD vs harmonic scalpel N of participants: 34 (1 RCT) · Women with symptoms of PCOS
1 finding from 1 review
- Ovarian surgery for symptom relief in women with polycystic ovary syndrome 2017 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedVery low
LOD vs medical interventions
Improvement in androgenic symptoms · Women with symptoms of PCOS
LOD showed no clear difference in improvement in androgenic symptoms at 6 months (hirsutism/acne) ‐… compared with medical interventions (low certainty).
1 finding from 1 review
- Ovarian surgery for symptom relief in women with polycystic ovary syndrome 2017 · Cochrane Headline outcomes onlyOR 1 [0.42, 2.37]Studies not reportedLow
LOD vs medical interventions
Harms: GI Upset at 6 months ‐ LOD vs metformin + clomiphene N of participants: 332 (2 RCTs) Harms: OHSS rates at 6 months ‐ LOD vs gonadotrophins N of participants: 33 (1 RCT) · Women with symptoms of PCOS
LOD probably leads to lower harms: GI Upset at 6 months ‐ LOD vs metformin + clomiphene N of… compared with medical interventions (moderate certainty).
1 finding from 1 review
- Ovarian surgery for symptom relief in women with polycystic ovary syndrome 2017 · Cochrane Headline outcomes onlyOR 0.05 [0.01, 0.36]Studies not reportedModerate
Oral contraceptive pill (OCP) vs metformin combined with OCP
Hirsutism ‐ Clinical F‐G score · aAdult women with PCOS
1 finding from 1 review
- Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes onlyno estimate extracted6 studies · 389 participantsLow
Oral contraceptive pill (OCP) vs metformin combined with OCP
Adverse events ‐ Severe · aAdult women with PCOS
Oral contraceptive pill (OCP) may leads to lower adverse events ‐ Severe compared with metformin combined with OCP (low certainty).
1 finding from 1 review
- Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes onlyOR 0.2 [0.06, 0.72]5 studies · 228 participantsLow
Oral contraceptive pill (OCP) vs metformin combined with OCP
Minor adverse events · aAdult women with PCOS
Oral contraceptive pill (OCP) may leads to lower adverse events ‐ Minor compared with metformin combined with OCP (low certainty).
1 finding from 1 review
- Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes onlyOR 0.06 [0.01, 0.44]2 studies · 98 participantsLow
Oral contraceptive pill (OCP) vs metformin combined with OCP
Improved menstrual pattern · aAdult women with PCOS
The review found no eligible studies for this question.
1 finding from 1 review
- Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found