Findings

What do systematic reviews say?

373 questions · 383 findings · 25 reviews · Hepato-Biliary

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No studies found 62 · 16.2%GRADE not reported 3 · 0.8%Very low 259 · 67.6%Low 51 · 13.3%Moderate 7 · 1.8%High 1 · 0.3%

Intervention not reported

Health‐related quality of life · people with liver metastases

The review found no eligible studies for this question.

1 finding from 1 review

Cryotherapy for liver metastases 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Tumour response measures · people with liver metastases

1 finding from 1 review

Cryotherapy for liver metastases 2019 · Cochrane Headline outcomes only
30
69 participants
Low

Cysteamine vs methionine (randomised trials)

All‐cause mortality · people with paracetamol (acetaminophen) overdose

1 finding from 1 review

Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 27 participants
Very low

Cysteamine vs methionine (randomised trials)

Hepatotoxicity (aspartate aminotransferase > 1000 IU/L) · people with paracetamol (acetaminophen) overdose

It is very uncertain whether cysteamine changes hepatotoxicity (aspartate aminotransferase > 1000 U/L) compared with methionine (randomised trials) (very low certainty).

1 finding from 1 review

Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
OR 0.92 [0.05, 16.46]
1 study · 27 participants
Very low

Intervention not reported

Interventions · people with liver cirrhosis and oesophageal varices with no history of bleeding

The review found no eligible studies for this question.

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Portocaval shunt(No direct RCT) · people with liver cirrhosis and oesophageal varices with no history of bleeding

It is very uncertain whether the intervention changes portocaval shunt(No direct RCT) (very low certainty).

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
HR 0.51 [0.06, 2.92]
Studies not reported
Very low

Intervention not reported

Variceal band ligation(5 RCTs, 372 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

It is very uncertain whether the intervention changes variceal band ligation(5 RCTs, 372 participants) (very low certainty).

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
OR 0.75 [0.02, 23.24]
Studies not reported
Very low

Intervention not reported

Sclerotherapy(1 RCT, 85 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

It is very uncertain whether the intervention changes sclerotherapy(1 RCT, 85 participants) (very low certainty).

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
OR 0.55 [0, 272.05]
Studies not reported
Very low

Intervention not reported

Variceal band ligation(1 RCT, 168 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

No active intervention(2 RCTs, 256 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

It is very uncertain whether the intervention changes no active intervention(2 RCTs, 256 participants) (very low certainty).

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
OR 0.28 [0.02, 2.91]
Studies not reported
Very low

Intervention not reported

Variceal band ligation(7 RCTs, 728 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

It is very uncertain whether the intervention changes variceal band ligation(7 RCTs, 728 participants) (very low certainty).

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
OR 1.6 [0.54, 5.15]
Studies not reported
Very low

Intervention not reported

Sclerotherapy(No direct RCT) · people with liver cirrhosis and oesophageal varices with no history of bleeding

It is very uncertain whether the intervention changes sclerotherapy(No direct RCT) (very low certainty).

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
OR 1.19 [0.02, 80.24]
Studies not reported
Very low

Intervention not reported

Beta‐blockers + nitrates(1 RCT, 57 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

The intervention may leads to higher beta‐blockers + nitrates(1 RCT, 57 participants) (low certainty).

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
OR 3.41 [1.11, 11.28]
Studies not reported
Low

Intervention not reported

No active intervention(No direct RCT) · people with liver cirrhosis and oesophageal varices with no history of bleeding

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Variceal band ligation(4 RCTs, 480 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Beta‐blockers · people with liver cirrhosis and oesophageal varices with no history of bleeding

The review found no eligible studies for this question.

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Sclerotherapy(2 RCTs, 90 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Beta‐blockers + variceal band ligation(1 RCT, 140 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

No active intervention(1 RCT, 161 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

It is very uncertain whether the intervention changes no active intervention(1 RCT, 161 participants) (very low certainty).

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
HR 1.36 [0.35, 5.8]
Studies not reported
Very low

Intervention not reported

Variceal band ligation(5 RCTs, 380 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

It is very uncertain whether the intervention changes variceal band ligation(5 RCTs, 380 participants) (very low certainty).

1 finding from 1 review

Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes only
HR 1.41 [0.83, 2.43]
Studies not reported
Very low