Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,410 questions · 8,901 findings · 1,091 reviews

No studies found 1,687 · 19%GRADE not reported 1,469 · 16.5%Very low 1,969 · 22.1%Low 2,060 · 23.1%Moderate 1,302 · 14.6%High 414 · 4.7%

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Summary of findings table ‐ Low‐carbohydrate weight‐reducing diets vs balanced‐carbohydrate weight‐reducing diets

Constipation · overweight and obese participants with T2DM (weight‐reducing phase only)

It is very uncertain whether summary of findings table ‐ Low‐carbohydrate weight‐reducing diets changes constipation at 3 to < 12 months compared with balanced‐carbohydrate weight‐reducing diets (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Low‐carbohydrate weight‐reducing diets vs balanced‐carbohydrate weight‐reducing diets

Number of participants per group with weight loss of at least 5% at ≥ 12 months · overweight and obese participants without T2DM (weight‐reducing phase only)

It is very uncertain whether summary of findings table ‐ Low‐carbohydrate weight‐reducing diets changes number of participants per group with weight loss of at least 5% at… compared with balanced‐carbohydrate weight‐reducing diets (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Low‐carbohydrate weight‐reducing diets vs balanced‐carbohydrate weight‐reducing diets

Cardiovascular mortality ‐ not measured · overweight and obese participants without T2DM (weight‐reducing phase only)

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Low‐carbohydrate weight‐reducing diets vs balanced‐carbohydrate weight‐reducing diets

Constipation · overweight and obese participants without T2DM (weight‐reducing phase only)

It is very uncertain whether summary of findings table ‐ Low‐carbohydrate weight‐reducing diets changes constipation at 3 to < 12 months compared with balanced‐carbohydrate weight‐reducing diets (very low certainty).

1 finding from 1 review

Upper clear plastic retainer + lower fixed canine-to-canine retainer vs Upper clear plastic retainer + lower interproximal reduction (adjunctive), no lower retainer

Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment

Upper clear plastic retainer + lower fixed canine-to-canine retainer showed no clear difference in stability: Little's Irregularity Index (lower arch) compared with upper clear plastic retainer + lower interproximal reduction…; GRADE not reported.

1 finding from 1 review

Low‐cavity forceps vs any vacuum cup

Third‐ or fourth‐degree perineal tear (with or without episiotomy) · Women in the second stage of labour, requiring an assisted vaginal birth

It is very uncertain whether low‐cavity forceps changes third‐ or fourth‐degree perineal tear (with or without episiotomy) compared with any vacuum cup (very low certainty).

1 finding from 1 review

Low‐cavity forceps vs any vacuum cup

Failed delivery with allocated instrument (primary) · Women in the second stage of labour, requiring an assisted vaginal birth

It is very uncertain whether low‐cavity forceps changes failed delivery with allocated instrument (primary) compared with any vacuum cup (very low certainty).

1 finding from 1 review

Low‐cavity forceps vs any vacuum cup

Any maternal trauma (primary) · Women in the second stage of labour, requiring an assisted vaginal birth

It is very uncertain whether low‐cavity forceps changes any maternal trauma (primary) compared with any vacuum cup (very low certainty).

1 finding from 1 review

Low‐dose colchicine vs placebo

Participant global assessment of treatment success: proportion with 50% or greater decrease in pain score from baseline ‐ 32 to 36 hours · acute gout

Low‐dose colchicine may leads to higher participant global assessment of treatment success: proportion with… compared with placebo (low certainty).

1 finding from 1 review

Low‐dose colchicine vs NSAIDs

Global assessment of treatment success · acute gout

Low‐dose colchicine showed no clear difference in participant global assessment of treatment success: Completely… compared with NSAIDs (low certainty).

1 finding from 1 review

Low‐dose colchicine vs NSAIDs

Reduction of inflammation ‐ not measured · acute gout

The review found no eligible studies for this question.

1 finding from 1 review

Low‐dose colchicine vs NSAIDs

Function of target joint ‐ not measured · acute gout

The review found no eligible studies for this question.

1 finding from 1 review