Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,661 questions · 2,751 findings · 453 reviews

No studies found 593 · 21.6%GRADE not reported 277 · 10.1%Very low 538 · 19.6%Low 712 · 25.9%Moderate 516 · 18.8%High 115 · 4.2%

Naloxone + oxycodone prolonged release tablets vs oxycodone

Laxation response: risk of spontaneous rescue‐free bowel movements in the medium termb · people with cancer irrespective of whether they were receiving palliative care opioid‐induced bowel dysfunction

The review found no eligible studies for this question.

1 finding from 1 review

Naloxone + oxycodone prolonged release tablets vs oxycodone

Symptoms of opioid withdrawal in the medium term · people with cancer irrespective of whether they were receiving palliative care opioid‐induced bowel dysfunction

Naloxone + oxycodone prolonged release tablets showed no clear difference in symptoms of opioid withdrawalfin the medium termb compared with oxycodone prolonged‐released tablets (low certainty).

1 finding from 1 review

Naloxone + oxycodone prolonged release tablets vs oxycodone

Serious adverse eventsg · people with cancer irrespective of whether they were receiving palliative care opioid‐induced bowel dysfunction

It is very uncertain whether naloxone + oxycodone prolonged release tablets changes serious adverse eventsg compared with oxycodone prolonged‐released tablets (very low certainty).

1 finding from 1 review

Naloxone + oxycodone prolonged release tablets vs oxycodone

Adverse events · people with cancer irrespective of whether they were receiving palliative care opioid‐induced bowel dysfunction

Naloxone + oxycodone prolonged release tablets showed no clear difference in adverse events compared with oxycodone prolonged‐released tablets (low certainty).

1 finding from 1 review

Long‐acting beta2‐agonists vs placebo

Quality of life St George's Respiratory Questionnaire (SGRQ) score · patients with chronic obstructive pulmonary disease

Long‐acting beta2‐agonists showed no clear difference in quality of life1 St George's Respiratory Questionnaire (SGRQ); lower… compared with placebo (moderate certainty).

1 finding from 1 review

Long‐acting beta2‐agonists vs placebo

Moderate exacerbations (course of antibiotics or oral steroids) · patients with chronic obstructive pulmonary disease

Long‐acting beta2‐agonists probably leads to lower moderate exacerbations (course of antibiotics or oral steroids) compared with placebo (moderate certainty).

1 finding from 1 review

Long‐acting beta2‐agonists vs placebo

Moderate‐to‐severe exacerbations (rate) · patients with chronic obstructive pulmonary disease

Long‐acting beta2‐agonists showed no clear difference in severe/moderate exacerbations (hospitalisation or course of… compared with placebo (moderate certainty).

1 finding from 1 review

Long‐acting beta2‐agonists vs placebo

Participants with one or more serious adverse event (non‐fatal) · patients with chronic obstructive pulmonary disease

Long‐acting beta2‐agonists showed no clear difference in participants with one or more serious adverse event (non‐fatal) compared with placebo (moderate certainty).

1 finding from 1 review

Long‐acting FSH (all doses) vs daily FSH

Live birth rate

Long‐acting FSH (all doses) probably leads to lower live birth rate ‐ Low dose (60 to 120 μg) compared with daily FSH (moderate certainty).

3 findings from 1 review

Long‐term GnRH agonist therapy vs no additional therapy

Live birth rate · patients with endometriosis prior to standard IVF/ICSI

It is very uncertain whether long‐term GnRH agonist therapy changes live birth rate compared with no additional therapy (very low certainty).

1 finding from 1 review

Long‐term GnRH agonist therapy vs no additional therapy

Complication rate · patients with endometriosis prior to standard IVF/ICSI

It is very uncertain whether long‐term GnRH agonist therapy changes complication rate compared with no additional therapy (very low certainty).

1 finding from 1 review

Long‐term GnRH agonist therapy vs no additional therapy

Clinical pregnancy rate · patients with endometriosis prior to standard IVF/ICSI

It is very uncertain whether long‐term GnRH agonist therapy changes clinical pregnancy rate compared with no additional therapy (very low certainty).

1 finding from 1 review