Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

94 questions · 102 findings · 12 reviews · Vascular

No studies found 16 · 15.7%GRADE not reported 1 · 1%Very low 17 · 16.7%Low 32 · 31.4%Moderate 27 · 26.5%High 9 · 8.8%

IPC plus pharmacological prophylaxis vs IPC alone

Incidence of DVTc (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

IPC plus pharmacological prophylaxis may leads to lower incidence of DVTc (early postoperative period) compared with IPC alone (low certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs IPC alone

Incidence of bleedingd (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

It is very uncertain whether IPC plus pharmacological prophylaxis changes incidence of bleedingd (early postoperative period) compared with IPC alone (very low certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs IPC alone

Incidence of major bleedingf (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

It is very uncertain whether IPC plus pharmacological prophylaxis changes incidence of major bleedingf (early postoperative period) compared with IPC alone (very low certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone

Incidence of PEa (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

IPC plus pharmacological prophylaxis may leads to lower incidence of PEa (early postoperative period) compared with pharmacological prophylaxis alone (low certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone

Incidence of DVTc (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

IPC plus pharmacological prophylaxis leads to lower incidence of DVTc (early postoperative period) compared with pharmacological prophylaxis alone (high certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone

Incidence of bleedingd (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

It is very uncertain whether IPC plus pharmacological prophylaxis changes incidence of bleedinge (early postoperative period) compared with pharmacological prophylaxis alone (very low certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs pharmacological prophylaxis alone

Incidence of major bleedingg (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

It is very uncertain whether IPC plus pharmacological prophylaxis changes incidence of major bleedingg (early postoperative period) compared with pharmacological prophylaxis alone (very low certainty).

1 finding from 1 review

Does normal saline flushing in long‐term central venous catheters (CVC) prevent occlusion vs heparin flushing

CVC occlusion rate per 1000 catheter days Ability to infuse solution through CVC · infants and children with a long‐term CVC

It is very uncertain whether does normal saline flushing in long‐term central venous catheters… changes CVC occlusion rate per 1000 catheter days: ability to infuse… compared with heparin flushing (very low certainty).

1 finding from 1 review

Does normal saline flushing in long‐term central venous catheters (CVC) prevent occlusion vs heparin flushing

CVC‐associated blood stream infection rate per 1000 catheter days Incidence of positive blood culture · infants and children with a long‐term CVC

Does normal saline flushing in long‐term central venous catheters… showed no clear difference in CVC‐associated blood stream infection rate per 1000 catheter days:… compared with heparin flushing (low certainty).

1 finding from 1 review