Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

178 questions · 188 findings · 16 reviews · Metabolic and Endocrine Disorders

No studies found 75 · 39.9%GRADE not reported 2 · 1.1%Very low 30 · 16%Low 55 · 29.3%Moderate 25 · 13.3%High 1 · 0.5%

Intervention not reported

Potency/bioactivity parameters of human insulin · healthy physicians

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

All‐cause mortality a. Intervention vs placebo [30 weeks to 4.75 years] b. Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus

The intervention showed no clear difference in all‐cause mortality a. Intervention vs placebo [30 weeks to 4.75… (low certainty).

1 finding from 1 review

Intervention not reported

Cancer a. Intervention vs thiazolidinediones [52 weeks to 4 years] b. Intervention vs insulin [6 years to 10 years] · participants with type 2 diabetes mellitus

The intervention showed no clear difference in cancer a. Intervention vs thiazolidinediones [52 weeks to 4 years]… (low certainty).

1 finding from 1 review

Intervention not reported

Health‐related quality of life a. Intervention vs thiazolidinediones [12 months] b. Intervention vs insulin [6 years] c. Intervention vs alpha‐glucosidase inhibitors [12 months] · participants with type 2 diabetes mellitus
1 finding from 1 review

Intervention not reported

Cardiovascular mortality a. Intervention vs placebo [30 weeks to 4.75 years] b. Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus

The intervention may leads to higher cardiovascular mortality a. Intervention vs placebo [30 weeks to… (low certainty).

1 finding from 1 review

Intervention not reported

Non‐fatal macrovascular outcomes 1. Composite 2. Non‐fatal myocardial infarction Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus

The intervention showed no clear difference in non‐fatal macrovascular outcomes 1. Composite 2. Non‐fatal… (low certainty).

1 finding from 1 review

Intervention not reported

Cancer Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus

The intervention showed no clear difference in cancer Intervention vs insulin [4.75 years to 10.0 years] (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality a. Intervention vs metformin [a. 24 weeks to 4 years] b. Intervention vs thiazolidinediones [b. 24 weeks to 4 years] c. Intervention vs insulin [c. 9 months to 10 years] d. Intervention vs incretin‐based control [d. 52 weeks to... · participants with type 2 diabetes mellitus

The intervention showed no clear difference in all‐cause mortality a. Intervention vs metformin [a. 24 weeks to 4… (low certainty).

1 finding from 1 review

Intervention not reported

Cardiovascular mortality a. Intervention vs metformin [a. 24 weeks to 4 years] b. Intervention vs thiazolidinediones [b. 24 weeks to 4 years] c. Intervention vs insulin [c. 9 months to 10 years] d. Intervention vs meglitinide [d. 12 months to 17 m... · participants with type 2 diabetes mellitus

The intervention showed no clear difference in cardiovascular mortality a. Intervention vs metformin [a. 24 weeks… (low certainty).

1 finding from 1 review