Findings

What do systematic reviews say?

85 questions · 85 findings · 13 reviews · Airways

No studies found 10 · 11.8%GRADE not reported 4 · 4.7%Very low 11 · 12.9%Low 25 · 29.4%Moderate 30 · 35.3%High 5 · 5.9%

Serious adverse events · adult parapneumonic effusions and empyema

Alteplase may leads to higher serious adverse events compared with urokinase (low certainty).

1 finding from 1 review

All‐cause mortality · adult parapneumonic effusions and empyema

Streptokinase showed no clear difference in mortality compared with urokinase (low certainty).

1 finding from 1 review

Referral for thoracic surgery (open or thorascopic) · adult parapneumonic effusions and empyema

Streptokinase showed no clear difference in referral for thoracic surgery (open or thorascopic) compared with urokinase (low certainty).

1 finding from 1 review

Serious adverse events · adult parapneumonic effusions and empyema

Streptokinase showed no clear difference in serious adverse events compared with urokinase (low certainty).

1 finding from 1 review

All‐cause mortality · adult parapneumonic effusions and empyema

Alteplase showed no clear difference in mortality compared with urokinase (low certainty).

1 finding from 1 review