Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

179 questions · 184 findings · 37 reviews

No studies found 34 · 18.5%GRADE not reported 6 · 3.3%Very low 56 · 30.4%Low 56 · 30.4%Moderate 23 · 12.5%High 9 · 4.9%

Combination chemotherapy vs single‐agent chemotherapy

Toxicity ‐ early adverse events G3/4 · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery

Combination chemotherapy probably leads to higher toxicity ‐ early adverse events G3/4 compared with single‐agent chemotherapy (moderate certainty).

1 finding from 1 review

Suprapubic catheterisation vs intermittent self‐catheterisation

Adverse events (acute complication after surgery)

It is very uncertain whether suprapubic catheterisation changes adverse events (acute complication after surgery) compared with intermittent self‐catheterisation (very low certainty).

1 finding from 1 review

Suprapubic catheterisation vs intermittent self‐catheterisation

Urinary tract infection

It is very uncertain whether suprapubic catheterisation changes urinary tract infections in the first month after surgery compared with intermittent self‐catheterisation (very low certainty).

1 finding from 1 review

Laparoscopy vs laparotomy

Overall survival (survival until death from all causes) · adult women diagnosed with early stage (I to IIa) endometrial cancer undergoing surgery as primary treatment.

Laparoscopy showed no clear difference in overall survival (survival until death from all causes) compared with laparotomy (moderate certainty).

1 finding from 1 review

Laparoscopy vs laparotomy

Serious adverse events (range of outcomes) · adult women diagnosed with early stage (I to IIa) endometrial cancer undergoing surgery as primary treatment.

Laparoscopy showed no clear difference in serious adverse events (range of outcomes) compared with laparotomy (low certainty).

1 finding from 1 review

Absorbable vs non‐absorbable sutures

Postoperative pain: early pain (10 days postoperatively) VAS 0 to 10 Verbal reporting scale No pain‐mild pain‐moderate pain‐severe pain (converted to numerical scale (0 to 3, 3 to 6, 6 to 10)
2 findings from 1 review

Intervention not reported

Early postoperative non‐thrombotic complications · Individuals with peripheral arterial disease

The intervention showed no clear difference in early postoperative non‐thrombotic complications (high certainty).

1 finding from 1 review

Laser ablation vs radiofrequency ablation

Cancer‐related mortality at maximal · people with early‐ or very early‐stage hepatocellular carcinoma ineligible for surgery

It is very uncertain whether laser ablation changes cancer‐related mortality at maximal compared with radiofrequency ablation (very low certainty).

1 finding from 1 review

Laser ablation vs radiofrequency ablation

Serious adverse events (number of participants) · people with early‐ or very early‐stage hepatocellular carcinoma ineligible for surgery

It is very uncertain whether laser ablation changes serious adverse events (number of participants) compared with radiofrequency ablation (very low certainty).

1 finding from 1 review