Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

110 questions · 112 findings · 12 reviews · Headline outcomes only

No studies found 11 · 9.8%GRADE not reported 14 · 12.5%Very low 22 · 19.6%Low 31 · 27.7%Moderate 23 · 20.5%High 11 · 9.8%

Amantidine vs antidepressants

Risk for at least one adverse event per patient · patients with the treatment of cocaine dependence

Amantidine showed no clear difference in adverse events as N of participants with at least one adverse event compared with antidepressants (low certainty).

1 finding from 1 review

Amantadine vs placebo

Risk for at least one adverse event per patient · patients with the treatment of cocaine dependence

Amantadine showed no clear difference in adverse events as N of participants with at least one adverse event compared with placebo (moderate certainty).

1 finding from 1 review