Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

125 questions · 126 findings · 14 reviews · Headline outcomes only

No studies found 29 · 23%GRADE not reported 2 · 1.6%Very low 37 · 29.4%Low 50 · 39.7%Moderate 8 · 6.3%High 0 · 0%

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants achieving control of inflammation (higher number of events is better) · NIIPPU

It is very uncertain whether steroids with or without azathioprine changes proportion of participants achieving control of inflammation (higher… compared with cyclosporine A (very low certainty).

1 finding from 1 review

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants achieving steroid‐sparing control (higher number of events is better) · NIIPPU

It is very uncertain whether steroids with or without azathioprine changes proportion of participants achieving steroid‐sparing control (higher… compared with cyclosporine A (very low certainty).

1 finding from 1 review

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants experiencing complications or requiring cessation of medication (lower number of events is better) · NIIPPU

It is very uncertain whether steroids with or without azathioprine changes proportion of participants experiencing complications or requiring… compared with cyclosporine A (very low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in TBUT (seconds) (longer is favored) · people with dry eye

Steroids showed no clear difference in change in TBUT (seconds) (longer is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in fluorescein corneal staining scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in fluorescein corneal staining scores (lower is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in tear osmolarity (mOsm/kg) (lower is favored) · people with dry eye

It is very uncertain whether steroids changes change in tear osmolarity (mOsm/kg) (lower is favored) compared with cyclosporine A (very low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Adverse effect: incident elevated IOP ( · people with dry eye

It is very uncertain whether steroids changes adverse effect: incident elevated IOP ( compared with cyclosporine A (very low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in patient‐reported symptom scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in patient‐reported symptom scores (lower is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in patient‐reported quality of life scores · people with dry eye

The review found no eligible studies for this question.

1 finding from 1 review