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What do systematic reviews say?

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Evidence found and GRADE certainty

356 questions · 373 findings · 42 reviews

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No studies found 47 · 12.6%GRADE not reported 21 · 5.6%Very low 68 · 18.2%Low 92 · 24.7%Moderate 97 · 26%High 48 · 12.9%

Pharmacological intervention and a form of psychotherapy (combination) vs pharmacological intervention and usual care or attention control (single)

Depression: meeting study criteria for depression at end of · people with depression after stroke
2 findings from 1 review

Pharmacological intervention and a form of psychotherapy (combination) vs pharmacological intervention and usual care or attention control (single)

Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke
1 finding from 1 review

Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension

Global assessment of treatment success · patients with adhesive capsulitis (frozen shoulder)

Combination of manual therapy and exercise following joint distension leads to higher global assessment of treatment success "Success, much improved,… compared with sham ultrasound following joint distension (high certainty).

1 finding from 1 review

Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension

Adverse events · patients with adhesive capsulitis (frozen shoulder)

Combination of manual therapy and exercise following joint distension leads to lower adverse events compared with sham ultrasound following joint distension (high certainty).

1 finding from 1 review

Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID

Global assessment of treatment success · patients with adhesive capsulitis (frozen shoulder)

Combination of manual therapy, exercise, electrotherapy and oral NSAID may leads to higher global assessment of treatment success "Disappearance of shoulder… compared with oral NSAID (low certainty).

1 finding from 1 review

Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID

Adverse events Pain persisting longer than 2 hours after treatment (during the 3‐week treatment period) · patients with adhesive capsulitis (frozen shoulder)

Combination of manual therapy, exercise, electrotherapy and oral NSAID may leads to higher adverse events Pain persisting longer than 2 hours after treatment… compared with oral NSAID (low certainty).

1 finding from 1 review