Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

119 questions · 121 findings · 22 reviews · Headline outcomes only

No studies found 12 · 9.9%GRADE not reported 7 · 5.8%Very low 36 · 29.8%Low 43 · 35.5%Moderate 19 · 15.7%High 4 · 3.3%

IM injection vs IA injection

Wound/ulcer healing: number of participants with healing ulcer · people with critical limb ischaemia

IM injection showed no clear difference in wound/ulcer healing: number of participants with healing ulcer compared with IA injection (low certainty).

1 finding from 1 review

IM injection vs IA injection

Improvement in lower limb perfusion: ABI · people with critical limb ischaemia

It is very uncertain whether IM injection changes improvement in lower limb perfusion: number of participants with… compared with IA injection (very low certainty).

1 finding from 1 review

IM injection vs IA injection

Improvement in lower limb perfusion: number of participants with improved TcO₂ reading · people with critical limb ischaemia

It is very uncertain whether IM injection changes improvement in lower limb perfusion: number of participants with… compared with IA injection (very low certainty).

1 finding from 1 review