Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

122 questions · 124 findings · 24 reviews

No studies found 12 · 9.7%GRADE not reported 10 · 8.1%Very low 36 · 29%Low 43 · 34.7%Moderate 19 · 15.3%High 4 · 3.2%

MSCs vs placebo or control

Incidence of chronic GvHD (prophylactic trials) · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

MSCs may leads to lower incidence of chronic GvHD (prophylactic trials) compared with control/placebo (low certainty).

1 finding from 1 review

MSCs vs placebo or control

Acute GvHD complete response (therapeutic trials) · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

It is very uncertain whether MSCs changes acute GvHD complete response (therapeutic trials) compared with control/placebo (very low certainty).

1 finding from 1 review

MSCs vs placebo or control

Chronic GvHD complete response (therapeutic trials) · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

It is very uncertain whether MSCs changes chronic GvHD complete response (therapeutic trials) compared with control/placebo (very low certainty).

1 finding from 1 review

IM injection vs IA injection

Wound/ulcer healing: number of participants with healing ulcer · people with critical limb ischaemia

IM injection showed no clear difference in wound/ulcer healing: number of participants with healing ulcer compared with IA injection (low certainty).

1 finding from 1 review

IM injection vs IA injection

Improvement in lower limb perfusion: ABI · people with critical limb ischaemia

It is very uncertain whether IM injection changes improvement in lower limb perfusion: number of participants with… compared with IA injection (very low certainty).

1 finding from 1 review

IM injection vs IA injection

Improvement in lower limb perfusion: number of participants with improved TcO₂ reading · people with critical limb ischaemia

It is very uncertain whether IM injection changes improvement in lower limb perfusion: number of participants with… compared with IA injection (very low certainty).

1 finding from 1 review