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What do systematic reviews say?

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Evidence found and GRADE certainty

92 questions · 92 findings · 12 reviews · Headline outcomes only

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No studies found 19 · 20.7%GRADE not reported 6 · 6.5%Very low 17 · 18.5%Low 24 · 26.1%Moderate 22 · 23.9%High 4 · 4.3%

Non‐integrated models of care ‐ Assertive community treatment only/Intensive case management/Specialised case management services vs usual care

General life satisfaction Quality of Life Interview section, scale of 1 to 7 · people with both severe mental illness and substance misuse

The review found no eligible studies for this question.

1 finding from 1 review

Non‐integrated models of care ‐ Assertive community treatment only/Intensive case management/Specialised case management services vs usual care

Lost to treatment · people with both severe mental illness and substance misuse

It is very uncertain whether non‐integrated models of care ‐ Assertive community treatment… changes leaving the study early: Lost to treatment compared with standard care (very low certainty).

1 finding from 1 review

Non‐integrated models of care ‐ Assertive community treatment only/Intensive case management/Specialised case management services vs usual care

Adverse event: Death ‐ not measured · people with both severe mental illness and substance misuse

The review found no eligible studies for this question.

1 finding from 1 review

Universal screening vs case finding

Thyroid dysfunction diagnosed in pregnancy: hyperthyroid · women during pregnancy

Universal screening showed no clear difference in thyroid dysfunction diagnosed in pregnancy: hyperthyroid compared with case finding (moderate certainty).

1 finding from 1 review