Findings

What do systematic reviews say?

124 questions · 127 findings · 17 reviews

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No studies found 32 · 25.2%GRADE not reported 11 · 8.7%Very low 53 · 41.7%Low 18 · 14.2%Moderate 13 · 10.2%High 0 · 0%

Opioids vs chlorpromazine

Neonatal or infant mortality · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs chlorpromazine

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs chlorpromazine

Length of hospital stay · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs chlorpromazine

Days treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 76 participants
Low

Opioids vs chlorpromazine

Adverse events (treatment related) · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 90 participants
Low

HALOPERIDOL vs chlorpromazine

Symptoms of delirium within 24 hoursa · terminally ill adults with delirium

The review found no eligible studies for this question.

1 finding from 1 review

Drug therapy for delirium in terminally ill adults 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HALOPERIDOL vs chlorpromazine

Symptoms of delirium between 24 and 48 hoursa · terminally ill adults with delirium

It is very uncertain whether summary of findings: haloperidol changes symptoms of delirium between 24 and 48 hoursa compared with chlorpromazine (very low certainty).

1 finding from 1 review

Drug therapy for delirium in terminally ill adults 2020 · Cochrane Headline outcomes only
MD 0.37
1 study · 24 participants
Very low

HALOPERIDOL vs chlorpromazine

Specific behaviour ‐ agitation · terminally ill adults with delirium

The review found no eligible studies for this question.

2 findings from 1 review

Drug therapy for delirium in terminally ill adults 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Drug therapy for delirium in terminally ill adults 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HALOPERIDOL vs chlorpromazine

Adverse events including extrapyramidal effects · terminally ill adults with delirium

It is very uncertain whether summary of findings: haloperidol changes adverse events including extrapyramidal effectsc compared with chlorpromazine (very low certainty).

1 finding from 1 review

Drug therapy for delirium in terminally ill adults 2020 · Cochrane Headline outcomes only
MD 0.46
1 study · 24 participants
Very low

Benzodiazepines (lorazepam) vs chlorpromazine

Symptoms of delirium within 24 hoursa · terminally ill adults with delirium

The review found no eligible studies for this question.

1 finding from 1 review

Drug therapy for delirium in terminally ill adults 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzodiazepines (lorazepam) vs chlorpromazine

Symptoms of delirium between 24 and 48 hoursa · terminally ill adults with delirium

It is very uncertain whether summary of findings: lorazepam changes symptoms of delirium between 24 and 48 hoursa compared with chlorpromazine (very low certainty).

1 finding from 1 review

Drug therapy for delirium in terminally ill adults 2020 · Cochrane Headline outcomes only
MD 5.25
1 study · 19 participants
Very low

Benzodiazepines (lorazepam) vs chlorpromazine

Specific behaviour ‐ agitation · terminally ill adults with delirium

The review found no eligible studies for this question.

2 findings from 1 review

Drug therapy for delirium in terminally ill adults 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Drug therapy for delirium in terminally ill adults 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzodiazepines (lorazepam) vs chlorpromazine

Adverse events including extrapyramidal effects · terminally ill adults with delirium

It is very uncertain whether summary of findings: lorazepam changes number of adverse events including extrapyramidal effectsc compared with chlorpromazine (very low certainty).

1 finding from 1 review

Drug therapy for delirium in terminally ill adults 2020 · Cochrane Headline outcomes only
MD 7.12
1 study · 18 participants
Very low

Benzodiazepines (lorazepam) vs chlorpromazine

Mortality from all causes · adult AIDS patients with delirium

It is very uncertain whether benzodiazepines (lorazepam) changes mortality from all causes compared with antipsychotics (chlorpromazine) (very low certainty).

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
RR 0.87 [0.23, 3.26]
1 study · 19 participants
Very low

Benzodiazepines (lorazepam) vs chlorpromazine

Length of delirium episode · adult AIDS patients with delirium

The review found no eligible studies for this question.

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzodiazepines (lorazepam) vs chlorpromazine

Severity of delirium · adult AIDS patients with delirium

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Very low

Benzodiazepines (lorazepam) vs chlorpromazine

Any adverse event ESRS, higher = worse · adult AIDS patients with delirium

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Very low

Benzodiazepines (lorazepam) vs chlorpromazine

Duration of hospital admission (days) · adult AIDS patients with delirium

The review found no eligible studies for this question.

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Lithium vs chlorpromazine

Efficacy: response (categorical) MSRS/YMRS ≥ 50% decrease in score by end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Lithium vs chlorpromazine

Efficacy: response (continuous) change in BPRS (total) from baseline to end of study ‐all data · acute mania

1 finding from 1 review

Lithium for acute mania 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 284 participants
Very low