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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Etretinate with PUVA therapy as co‐intervention vs placebo with PUVA therapy

Proportion of participants with adverse effects ‐ measured over 8 weeks · chronic palmoplantar pustulosis

It is very uncertain whether etretinate with PUVA therapy as co‐intervention changes proportion of participants with adverse effects ‐ measured over 20… compared with placebo with PUVA therapy (very low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy vs conventional laser/cryotherapy

Structural outcome ‐ retinal detachment · preterm infants with type 1 ROP

It is very uncertain whether anti‐vascular endothelial growth factor therapy changes structural outcome ‐ retinal detachment compared with conventional laser/cryotherapy (very low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy vs conventional laser/cryotherapy

Structural outcome ‐ complete retinal detachment (unit of analysis: eyes) · preterm infants with type 1 ROP

It is very uncertain whether anti‐vascular endothelial growth factor therapy changes structural outcome ‐ complete retinal detachment (unit of analysis:… compared with conventional laser/cryotherapy (very low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy vs conventional laser/cryotherapy

Refractive error ‐ very high myopia ‐ at 30 months of age (unit of analysis: eyes) · preterm infants with type 1 ROP

Anti‐vascular endothelial growth factor therapy may leads to lower refractive error ‐ very high myopia ‐ at 30 months of age (unit of… compared with conventional laser/cryotherapy (low certainty).

1 finding from 1 review